Results 81 to 90 of about 4,120 (178)
Therapeutic targeting of PRMT5 and mutant ACVR1 in paediatric glioma
, 2021 Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal paediatric brainstem tumour with a median overall survival of 9-11 months. The unique genetic, anatomical and developmental identity of the tumour means that there are currently no effective chemotherapies or targeted therapies.
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International physician survey on management of FOP: a modified Delphi study
Orphanet Journal of Rare Diseases, 2017 Fibrodysplasia ossificans progressiva (FOP), a disabling disorder of progressive heterotopic ossification (HEO), is caused by heterozygous gain-of- function mutations in Activin receptor A, type I (ACVR1, also known as ALK2), a bone morphogenetic protein
Maja Di Rocco +12 more
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Co-Crystallisation Of Acvr1 With Three Compounds - Fine Screen
, 2018 The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no.
Adamson, Roslin Jane +3 more
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Case Reports in Genetics, 2013 Fibrodysplasia ossificans progressiva (FOP) is an exceptionally rare genetic disease that is characterised by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomical areas. This disease is caused by
Rafael Herrera-Esparza +7 more
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ACVR1 Crystals at the Diamond Light Source – Beamline I04.
, 2019 Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen,
Williams, E.P., Bullock, A.N.
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BiomoleculesWhen a genetic disease is characterized by the abnormal activation of normal molecular pathways and cellular events, it is illuminating to critically examine the places and times of these activities both in health and disease.
O. Will Towler +2 more
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Purification Of Acvr1 Alone And Tgfbr1 (Alk5) Complexed With Fkbp12
, 2018 Purifications of ALK2 and ALK5 (the latter in complex with FKBP12) and crystal ...
Adamson, Roslin +3 more
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Momelotinib: Mechanism of action, clinical, and translational science
Clinical and Translational ScienceMyelofibrosis is a chronic myeloproliferative disorder characterized by bone marrow fibrosis, splenomegaly, anemia, and constitutional symptoms, with a median survival of ≈6 years from diagnosis.
Georgios Vlasakakis +8 more
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Another Acvr1 Purification For Fragment Screening And Co-Crystallisation
, 2018 A rather unsuccessful purification, but nevertheless, enough for three crystal plates to follow up compound ...
Adamson, Roslin +3 more
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