Results 81 to 90 of about 6,796 (211)

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, Volume 36, Issue 10, 2 February 2026.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers

Scientific Reports, 2021
The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in ...
Eirini Tarsani, Andreas Kranis, Gerasimos Maniatis, Ariadne L. Hager-Theodorides, Antonios Kominakis   +4 more
doaj   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

ACVR1 Crystals at the Diamond Light Source – Beamline I04.

, 2019
Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen,
Williams, E.P., Bullock, A.N.
openaire   +1 more source

MicroRNA-384 inhibits the progression of breast cancer by targeting ACVR1

Oncology Reports, 2018
Breast cancer is the leading cause of cancer-related deaths in females worldwide. Triple-negative breast cancer (TNBC) accounts for 15% of all breast cancer cases and has a poorer prognosis than other subtypes. Moreover, the treatment for breast cancer, especially for TNBC, remains unsatisfactory.
Wang, Yongxia, Zhang, Zheying, Wang, Jianqiang   +2 more
openaire   +3 more sources

Clinical Aspects and Current Therapeutic Approaches for FOP

Biomedicines, 2020
Fibrodysplasia ossificans progressiva (FOP) is an extremely rare heritable disorder of connective tissues characterized by progressive heterotopic ossification in various skeletal sites.
Hiroshi Kitoh
doaj   +1 more source

Heterotopic Ossification: Cellular Basis, Symptoms, and Treatment [PDF]

, 2012
Heterotopic ossification (HO) is the process by which calcified bone develops in soft tissues. Because of the abnormal calcification, complications such as bone deformation, loss of range of motion, and joint immobility adversely affect patients.
Wolfe, Brian
core  

Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours [PDF]

, 2017
Glioneuronal tumours are an important cause of treatment-resistant epilepsy. Subtypes of tumour are often poorly discriminated by histological features and may be difficult to diagnose due to a lack of robust diagnostic tools.
Apps, J, Brooks, T, Chalker, J, Cross, JH, Forshew, T, Gutteridge, A, Ham, J, Hargrave, D, Harkness, W, Hubank, M, Izquierdo Delgado, E, Jacques, TS, Keeley, A, Kristiansen, M, Mifsud, W, Stone, TJ, Thom, M, Tisdall, M, Virasami, A, Wilkhu, L   +19 more
core   +2 more sources

Update On Fragment Screening Of Acvr1 Co_Crystallised With Ldn_193189

, 2018
The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no.
Adamson, Roslin, Matteucci, Mizio, Brennan, Paul, Bullock, Alex   +3 more
openaire   +1 more source

ACVR1 Gene Mutation in Sporadic Korean Patients with Fibrodysplasia Ossificans Progressiva

Journal of Korean Medical Science, 2009
Fibrodysplasia ossificans progressiva (FOP; OMIM 135100) is a rare but extremely disabling genetic disorder of the skeletal system, and is characterized by the progressive development of ectopic ossification of skeletal muscles and subsequent joint ankylosis.
Lee, Dong Yeon, Cho, Tae-Joon, Lee, Hye Ran, Park, Moon Seok, Yoo, Won Joon, Chung, Chin Youb, Choi, In Ho   +6 more
openaire   +2 more sources