Results 91 to 100 of about 5,020 (198)

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

ACVR1-M4K2158 dataset and purification of TNIK and BMPR1A

, 2019
The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada, Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no.
Adamson, Roslin, Brennan, Paul, Bullock, Alex   +2 more
openaire   +1 more source

Determining the nanoBRET AL2K IC50 values of 24 new ACVR1/ALK2 inhibitors

, 2018
In an effort to develop clinical compounds for Diffused Intrinsic Pontine Glioma (DIPG) treatment, new analogues of ACVR1/ALK2 inhibitors are continuously synthesised by Ontario Institute for Cancer Research (OICR) and Charles River Laboratories (CRL). I
Alex, Jong Fu Wong, Jong Fu Wong (4949545), Alex (6929108)   +3 more
core   +1 more source

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

eLife, 2018
The best characterized signaling pathway downstream of transforming growth factor β (TGF-β) is through SMAD2 and SMAD3. However, TGF-β also induces phosphorylation of SMAD1 and SMAD5, but the mechanism of this phosphorylation and its functional relevance
Anassuya Ramachandran, Pedro Vizán, Debipriya Das, Probir Chakravarty, Janis Vogt, Katherine W Rogers, Patrick Müller, Andrew P Hinck, Gopal P Sapkota, Caroline S Hill   +9 more
doaj   +1 more source

Activin signaling in microsatellite stable colon cancers is disrupted by a combination of genetic and epigenetic mechanisms.

PLoS ONE, 2009
BackgroundActivin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon
Barbara Jung, Jessica Gomez, Eddy Chau, Jennifer Cabral, Jeffrey K Lee, Aimee Anselm, Przemyslaw Slowik, Deena Ream-Robinson, Karen Messer, Judith Sporn, Sung K Shin, C Richard Boland, Ajay Goel, John M Carethers   +13 more
doaj   +1 more source

A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva

, 2006
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification.
Morhart, R, Connor, J Michael, Roger Smith, LeMerrer, M, Connor, J. Michael, Michael Zasloff, Rogers, John G., Rogers, John G, Choi, IH, Xu, M, David A Fenstermacher, In Ho Choi, Martine LeMerrer, Brown, Matthew A., Morhart, Rolf, Eileen M Shore, Matthew A Brown, J Michael Connor, Cho, TJ, John G Rogers, Fenstermacher, David A., Meiqi Xu, Frederick S Kaplan, Kaplan, Frederick S., Feldman, George J., J Andoni Urtizberea, Glaser, David L, Feldman, GJ, Connor, JM, Rogers, JG, Shore, EM, Tae-Joon Cho, Triffitt, James T., Glaser, DL, Xu, Meiqi, Zasloff, Michael, Smith, R, Urtizberea, JA, Zasloff, M, Shore, Eileen M., Cho, Tae-Joon, Triffitt, James T, Delai, Patricia, Smith, Roger, James T Triffitt, Delai, P, Kaplan, FS, David L Glaser, Glaser, David L., Kaplan, Frederick S, Feldman, George J, Triffitt, JT, Urtizberea, J. Andoni, George J Feldman, Fenstermacher, DA, Fenstermacher, David A, Shore, Eileen M, Brown, MA, Urtizberea, J Andoni, LeMerrer, Martine, Choi, In Ho, Rolf Morhart, Patricia Delai, Brown, Matthew A   +63 more
core   +1 more source

ACVR1 Gene Mutation in Sporadic Korean Patients with Fibrodysplasia Ossificans Progressiva [PDF]

, 2009
Fibrodysplasia ossificans progressiva (FOP; OMIM 135100) is a rare but extremely disabling genetic disorder of the skeletal system, and is characterized by the progressive development of ectopic ossification of skeletal muscles and subsequent joint ...
Choi, In Ho, Park, Moon Seok, Cho, Tae-Joon, Lee, Hye Ran, Chung, Chin Youb, Yoo, Won Joon, Lee, Dong Yeon   +6 more
core   +1 more source

Effect of selected miRNAs on the expression of endogenous ACVR1/Alk-2 mRNA.

, 2012
Selected miRs were transfected in the indicated cell lines and expression of ACVR1/Alk-2 mRNA was measured by RT-qPCR and compared to the expression level of ACVR1/Alk-2 transcript from cells transfected with a negative scrambled pre-miR control ...
Renata Bocciardi (115174), Francesca Giacopelli (115166), Roberto Ravazzolo (115170), Serena Cappato (115162), Marzia Mura (115161)   +4 more
core   +1 more source

Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1 [PDF]

, 2008
Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant human disorder of bone formation that causes developmental skeletal defects and extensive debilitating bone formation within soft connective tissues (heterotopic ossification) during ...
Reardon, W., Stephen J. Forman, Stefan Mundlos, Bernhard Köster, Glaser, D.L., Fastnacht-Urban, E., Michael Zasloff, Connor, J.M., Seemann, P., Zasloff, M., Groppe, J., Elisabeth Fastnacht-Urban, William Reardon, Carroll, L., Frederick S. Kaplan, Gillessen-Kaesbach, G., Julie Hoover-Fong, Kaplan, F.S., Delai, P., Petra Seemann, Morhart, R., Mundlos, S., Koster, B., Zaidi, S.A., Richard M. Pauli, J. Michael Connor, Eileen M. Shore, Hoover-Fong, J., Pauli, R.M., Shore, E.M., Liam Carroll, Meiqi Xu, Rolf Morhart, Forman, S.J., Patricia Delai, Syed-Adeel Zaidi, Gabriele Gillessen-Kaesbach, David L. Glaser, Xu, M., Jay Groppe, Carroll, Liam, Zaidi, Syed-Adeel, Köster, Bernhard, Morhart, Rolf, Gillessen-Kaesbach, Gabriele, Hoover-Fong, Julie, Kaplan, Frederick S., Seemann, Petra, Xu, Meiqi, Reardon, William, Zasloff, Michael, Connor, Michael, Shore, Eileen M., Delai, Patricia, Fastnacht-Urban, Elisabeth, Mundlos, Stefan, Pauli, Richard M., Glaser, David L., Groppe, Jay, Forman, Stephen J.   +59 more
core   +1 more source

Recurrent ACVR1 mutations in posterior fossa ependymoma

Acta Neuropathologica, 2022
Pratt, Drew, Lucas, Calixto-Hope G, Selvam, Pavalan Panneer, Abdullaev, Zied, Ketchum, Courtney, Quezado, Martha, Armstrong, Terri S, Gilbert, Mark R, Papanicolau-Sengos, Antonios, Raffeld, Mark, Choo-Wosoba, Hyoyoung, Chan, Priya, Whipple, Nicholas, Nasrallah, MacLean, Santi, Mariarita, Ramaswamy, Vijay, Giannini, Caterina, Ritzmann, Timothy A, Grundy, Richard G, Burford, Anna, Jones, Chris, Hawkins, Cynthia, Venneti, Sriram, Solomon, David A, Aldape, Kenneth   +24 more
openaire   +2 more sources