Results 111 to 120 of about 6,796 (211)

Brainstem Glioma in Adults [PDF]

, 2016
Brainstem gliomas are not nearly as common in adults as they are in children. They are likely the final common consequence not of a single disease process but of several. They can be difficult to diagnose, and are challenging to treat.
Jethro Hu, Santosh Kesari, Stephen Western   +2 more
core   +2 more sources

Recurrent ACVR1 mutations in posterior fossa ependymoma

Acta Neuropathologica, 2022
Pratt, Drew, Lucas, Calixto-Hope G, Selvam, Pavalan Panneer, Abdullaev, Zied, Ketchum, Courtney, Quezado, Martha, Armstrong, Terri S, Gilbert, Mark R, Papanicolau-Sengos, Antonios, Raffeld, Mark, Choo-Wosoba, Hyoyoung, Chan, Priya, Whipple, Nicholas, Nasrallah, MacLean, Santi, Mariarita, Ramaswamy, Vijay, Giannini, Caterina, Ritzmann, Timothy A, Grundy, Richard G, Burford, Anna, Jones, Chris, Hawkins, Cynthia, Venneti, Sriram, Solomon, David A, Aldape, Kenneth   +24 more
openaire   +2 more sources

Heterotopic Ossification: Molecular Drivers, Subtype-Specific Mechanisms, and Translational Therapeutic Advances

Biomolecules
Heterotopic ossification (HO), the pathological formation of mature bone in non-skeletal soft tissues (e.g., muscles, tendons), severely impairs patient mobility and quality of life.
Sihong Chen, Hui Lin
doaj   +1 more source

Mutation Detection in Activin A Receptor, Type I (ACVR1) Gene in Fibrodysplasia Ossificans Progressiva in An Iranian Family [PDF]

Cell Journal, 2014
Fibrodysplasia Ossificans Progressiva (FOP, MIM 135100) is a rare genetic disease that is often inherited sporadically in an autosomal dominant pattern. The disease manifests in early life with malformed great toes and, its episodic and progressive bone ...
Ziba Morovvati, Saeid Morovvati, Gholamhossein Alishiri, Seyed Hossein Moosavi, Reza Ranjbar, Yaser Bolouki Moghaddam   +5 more
doaj  

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors [PDF]

, 2012
BACKGROUND: As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma.
Anne-Marie Cleton-Jansen, Brendy van den Akker, Burkhard Lehner, Judith VMG Bovée, Maayke van Ruler, Stephane Boeuf, Wiltrud Richter   +6 more
core   +1 more source

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. [PDF]

, 2017
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases.
Adam Resnick, Alan Mackay, Alexei N. Kisljakov, Andrew J. Martin, Andrew S. Moore, André O. von Bueren, Angel Montero Carcaboso, Angela J. Waanders, Anna Burford, Baker, Barrow, Bax, Bender, Bjerke, Bouffet, Buczkowicz, Cai, Cai, Carmen de Torres, Carvalho, Castel, Ceccarelli, Chan, Chris Jones, Christopher Chandler, Cynthia Hawkins, Darach Crimmins, David Castel, David T.W. Jones, Davis, Diana Carvalho, Dmitry M. Konovalov, Dorra H’mida-Ben Brahim, Elisa Izquierdo, Fontebasso, Fontebasso, Funato, Grasso, Hamid Nikbakht, Harry J. Han, Hennika, Henry C. Mandeville, Ho-Keung Ng, Jacques Grill, Janat Fazal-Salom, Jane Cryan, Jane Pears, Jaume Mora, John Caird, Jones, Jones, Jones, João N. Stavale, Kathryn R. Taylor, Khuong-Quang, Korshunov, Korshunov, Kramm, Kun Mu, Leslie R. Bridges, Louis, Lucas T. Bidinotto, Ludmila I. Shats, Lynley Marshall, Lynn Bjerke, Mara Vinci, Marie-Anne Debily, Mariona Sunol, Maryam Fouladi, Matthew Clarke, Meera Nandhabalan, Michael Baudis, Michael Farrell, Michelle Monje, Nada Jabado, Natacha Entz-Werle, Nicolaides, Northcott, Ofelia Cruz, Ostrom, Paugh, Paugh, Paugh, Pichai Raman, Puget, Qin, Richards, Rui M. Reis, Safa Al-Sarraj, Saoussen Trabelsi, Sara Temelso, Saumya Gupta, Schiffman, Schwartzentruber, Sergey Popov, Shlien, Stefan M. Pfister, Stergios Zacharoulis, Sturm, Sturm, Sucheta Vaidya, Suzanne J. Baker, Taylor, Taylor, Temime-Smaali, Temime-Smaali, Tiberi, Valeria Molinari, Venkatesh, Welcker, Wu, Wu, Wu, Xingang Li, Yada, Yang, Zarghooni   +116 more
core   +8 more sources

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

International physician survey on management of FOP: a modified Delphi study

Orphanet Journal of Rare Diseases, 2017
Fibrodysplasia ossificans progressiva (FOP), a disabling disorder of progressive heterotopic ossification (HEO), is caused by heterozygous gain-of- function mutations in Activin receptor A, type I (ACVR1, also known as ALK2), a bone morphogenetic protein
Maja Di Rocco, Genevieve Baujat, Marta Bertamino, Matthew Brown, Carmen L. De Cunto, Patricia L. R. Delai, Elisabeth M. W. Eekhoff, Nobuhiko Haga, Edward Hsiao, Richard Keen, Rolf Morhart, Robert J. Pignolo, Frederick S. Kaplan   +12 more
doaj   +1 more source

Cannabidiol stimulates AML-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner [PDF]

, 2015
Glioma stem-like cells (GSCs) correspond to a tumor cell subpopulation, involved in glioblastoma multiforme (GBM) tumor ini- tiation and acquired chemoresistance.
Amantini, Consuelo, Liberati, Sonia, Morelli, MARIA BEATRICE, Nabissi, Massimo, Pallini, Roberto, Ricci Vitiani, Lucia, Santoni, Giorgio, Santoni, Matteo   +7 more
core   +2 more sources

Therapeutic targeting of PRMT5 and mutant ACVR1 in paediatric glioma

, 2021
Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal paediatric brainstem tumour with a median overall survival of 9-11 months. The unique genetic, anatomical and developmental identity of the tumour means that there are currently no effective chemotherapies or targeted therapies.
openaire   +1 more source