Results 111 to 120 of about 5,020 (198)
Mutations in ACVR1 that result in Fibrodysplasia ossificans progressiva
, 2019 Analyzing the various point mutations in the coding of ACVR1 that result in connective tissue disease Fibrodysplasia ossificans progressiva by using various molecular dynamics ...
Weatherby, William
core
Case Reports in Genetics, 2013 Fibrodysplasia ossificans progressiva (FOP) is an exceptionally rare genetic disease that is characterised by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomical areas. This disease is caused by
Rafael Herrera-Esparza +7 more
doaj +1 more source
BiomoleculesWhen a genetic disease is characterized by the abnormal activation of normal molecular pathways and cellular events, it is illuminating to critically examine the places and times of these activities both in health and disease.
O. Will Towler +2 more
doaj +1 more source
Purification Of Acvr1 Alone And Tgfbr1 (Alk5) Complexed With Fkbp12
, 2018 Purifications of ALK2 and ALK5 (the latter in complex with FKBP12) and crystal ...
Adamson, Roslin +3 more
openaire +2 more sources
Determining the IC50 values of 30 legacy ACVR1/ALK2 inhibitors
, 2018 A large number of ACVR1/ALK2 inhibitors were previously synthesised by Paul Brenner’s team (Target Discovery Center, University of Oxford) for the purpose of treating Fibrodysplasia Ossificans Progressiva (FOP). Although these compounds were not designed
Wong, Jong Fu +3 more
core +2 more sources
Another Acvr1 Purification For Fragment Screening And Co-Crystallisation
, 2018 A rather unsuccessful purification, but nevertheless, enough for three crystal plates to follow up compound ...
Adamson, Roslin +3 more
openaire +1 more source
Momelotinib: Mechanism of action, clinical, and translational science
Clinical and Translational ScienceMyelofibrosis is a chronic myeloproliferative disorder characterized by bone marrow fibrosis, splenomegaly, anemia, and constitutional symptoms, with a median survival of ≈6 years from diagnosis.
Georgios Vlasakakis +8 more
doaj +1 more source
ACVR1 Allele-Specific Antisense Oligonucleotides
IPFS: QmNPT5Mzt9mwnFUreNhNsjjm4fECQT9Xjf5MNyAgT5pDMi. TX: 0xc6ffa10bd0cd44e5c98d54fe485efc5d46a4aaf1936f8bec57c4ea97a478c0b9. CC0.
openaire +1 more source
Imatinib Repurposing for ACVR1 Downstream Signaling Inhibition
IPFS: QmQp88cmTnfSNBeTvggvrqUSDn52KZcMXnUUUG6GwoJWNV. TX: 0x5d6e87921cd14d0ed369673eb4b9420a0b8f22cebd7cb561052d47a78accde68. CC0.
openaire +1 more source