Results 61 to 70 of about 2,169 (239)

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Conservation of a pH-sensitive structure in the C-terminal region of spider silk extends across the entire silk gene family [PDF]

, 2018
Spiders produce multiple silks with different physical properties that allow them to occupy a diverse range of ecological niches, including the underwater environment. Despite this functional diversity, past molecular analyses show a high degree of amino
A Drozdetskiy, A Rising, A Rising, A Rising, A Sponner, A Sponner, A Sponner, C Boutry, CY Hayashi, CY Hayashi, D Motriuk-Smith, D Schutz, D Schütz, D Schütz, D Schütz, E Gnesa, F Hagn, F Vollrath, G Askarieh, G Hormiga, I Agnarsson, J Perez-Rigueiro, JE Garb, JE Garb, K Tamura, KW Sanggaard, L Eisoldt, M Andersson, M Andersson, M Kearse, M Stark, MA Collin, MA Larkin, MB Hinman, MG Grabherr, Michelle Strickland, Milan Řezáč, Neil R. Thomas, PL Babb, R Beckwitt, RJ Challis, RS Seymour, S Ittah, S Ittah, Sara L. Goodacre, SJ Blamires, TA Blackledge, TA Blackledge, TH Clarke, TH Clarke, Victor Tudorica, W Nentwig   +51 more
core   +2 more sources

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

In vitro phosphorylation as tool for modification of silk and keratin fibrous materials [PDF]

, 2016
An overview is given of the recent work on in vitro enzymatic phosphorylation of silk fibroin and human hair keratin. Opposing to many chemical "conventional" approaches, enzymatic phosphorylation is in fact a mild reaction and the treatment falls within
A Bononi, A Ghosh, A Hezi-Yamit, A Kishida, A Matsumoto, A Nakamura, A Zanghellini, Artur Cavaco-Paulo, B Charmas, B Kundu, BS Eckert, C Weathersby, CN Laatsch, CZ Zhou, D Puglia, D Richards, DJ Mandell, DN Rockwood, ES Lintz, F Xin, FH Westheimer, G Kiss, H Lee, I Khan, J Biagiotti, J Liao, J McKittrick, K Fujihara, KR Jegannathan, LY Novoselova, M Emri, M Pekny, M Shen, MF Gavazzoni Dias, P Demarche, P Khurana, P Strnad, P Zhang, PA Coulombe, PL Yeagle, S Winkler, SK Mallapragada, T Armaroli, T Klapperstuck, T Yucel, TT Sun, V Volkov, V Volkov, V Volkov, V Volkov, Vadim Volkov, WQ Chen, X Hu, Y Xue, YL Shih   +54 more
core   +1 more source

Genipin‐Modified Silk‐Fibroin Nanometric Nets [PDF]

Macromolecular Bioscience, 2008
AbstractNanometric silk‐fibroin nets were fabricated by electrospinning from regenerated Bombyx mori silk‐fibroin (SF)/formic acid solutions with the addition of genipin (GE), 2, 15 and 24 h after the solution preparation. After spinning, the pure fibroin nanofibers were water soluble and needed a further stabilization process, whereas the reaction of ...
S. S. Silva, Maniglio, Devid, Motta, Antonella, J. F. Mano, R. L. Reis, Migliaresi, Claudio   +5 more
openaire   +4 more sources

Optoelectrical Devices for Neural Interfacing: Engineering Integration, Stability, and Multimodal Sensing

Advanced Healthcare Materials, EarlyView.
Implantable optoelectrical devices are an effective resource for the modulation and monitoring of neural activity with high spatiotemporal resolution. This review discusses current challenges faced by these devices and outlines future perspectives for the development of next‐generation neural interfaces targeting chronic, multisite, and multimodal ...
Stella Aslanoglou, Barbara Spagnolo, Antonio Balena, Massimo De Vittorio, Ferruccio Pisanello   +4 more
wiley   +1 more source

The oyster genome reveals stress adaptation and complexity of shell formation [PDF]

, 2012
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with ...
Andrew Mount, AS Mount, B Star, Baoyu Huang, Binghang Liu, Bo Wang, Bo Wen, C Sauvage, CA Lemmon, CE Bender, Christian E. W. Steinberg, Chunfang Peng, D Hedgecock, DD Mosser, DEK Ferrier, Dennis Hedgecock, Dingding Fan, DJ McGoldrick, E Sauvage, E Sodergren, EF Lee, EK Suk, ET Walters, F Marin, Fei Xu, Fengji Tan, Fucun Wu, Guofan Zhang, Guojie Zhang, Guoying Miao, H Li, Haigang Qi, Hailong Yang, Haiyan Wang, Huanming Yang, Huayong Que, JH Waite, Jiafeng Wang, Jian Wang, Jibiao Zhang, Jie Meng, Jinpeng Wang, JO Kitzman, Jordi Paps, Juan Li, Jun Liu, Jun Wang, Junyi Wang, JV Goldstone, K Caldeira, K Nagai, KS Small, Lan Yang, Li Chen, Li Li, Linlin Zhang, Longhai Luo, Lumin Qian, LW Hillier, M Barucca, M Stark, Maoshan Chen, Mei Yang, N Kourtis, Na Li, Na Zhang, Ning Li, Patrick M. Gaffney, PC Hanington, Peixiang Ni, Peizhou Cheng, Pengcheng Yang, Peter W. H. Holland, PM Gaffney, PS Galtsoff, Qiang Wang, Qihui Zhu, Qiumei Zheng, R Bonasio, R Li, R Li, RA Dalloul, Ronglian Huang, Ruibang Luo, S Keller, S Mathivanan, S Weiner, SC Talmage, Shan Wang, Shoudu Zhang, Shu Zhang, SM Zhang, T Furuhashi, Tao Qu, TM Carland, Tomislav Domazet-Lošo, Tong Wang, TS Chang, Wei Wang, Wen Huang, Wenjing Fu, WF Ponder, X Xu, Xiao Liu, Xiaodong Fang, Xiaoqing Sun, Xiaorui Song, Xiaotong Wang, Ximing Guo, Xuanting Jiang, Xuedi Du, Y Han, Yabing Zhu, Yan He, Yao Ming, Ye Yin, Yingrui Li, Yingxiang Li, Yinlong Xie, Yishuai Du, Yong Zhang, Yuanxin Chen, Yue Feng, Yunjie Liu, Zhe Xu, Zhicai She, Zhiqiang Xiong, Zhiyong Huang, Zhiyu Peng   +128 more
core   +1 more source

A Versatile Engineering Platform for the Fabrication of Prosthetic Venous Valves Using Electrospinning

Advanced Healthcare Materials, EarlyView.
Percutaneous prosthetic venous valves are fabricated by embedding stents in an electrospun matrix that extends luminally to form leaflets. The design shields leaflets from hyperplastic cells, isolates struts from blood contact, and avoids discrete anchoring points.
Dario Arcuti, Salma Mansi, Dominic Biebl, Malin Reuter, Maximilian Grab, José Carlos Rodríguez‐Cabello, Petra Mela   +6 more
wiley   +1 more source

Phosphorylated silk fibroin matrix for methotrexate release [PDF]

, 2015
Silk-based matrix was produced for delivery of a model anticancer drug, methotrexate (MTX). The calculation of net charge of silk fibroin and MTX was performed to better understand the electrostatic interactions during matrix formation upon casting. Silk
Gomes, A. C., Paulo, Artur Cavaco, Sárria, M. P., Volkov, Vadim   +3 more
core   +1 more source

Biofabrication of Endothelialized, Intrinsically Vascularized 3D‐Printed Recombinant Spider Silk Scaffolds

Advanced Healthcare Materials, EarlyView.
This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold, Stefanie Heltmann‐Meyer, Xuen J. Ng, Thomas Scheibel, Tobias Fey, Harald Wajant, Carol Geppert, Andreas Arkudas, Dominik Steiner, Raymund E. Horch   +9 more
wiley   +1 more source