Results 181 to 190 of about 196,664 (232)

Epigenetic Regulation of VCAM-1 by Lipoxin A4 Is Renoprotective Against Diabetic Kidney Disease. [PDF]

Diabetes
Bose M, Mohan M, Okabe J, Kaipananickal H, Priori V, Chhor C, Sourris KC, Radman R, Tikellis C, Zhang Y, El-Osta A, Brennan E, Guiry PJ, Gahan K, Tighe C, Thomas M, Jandeleit-Dahm K, Godson C, Kantharidis P, Cooper ME.   +19 more
europepmc   +1 more source

Jointless Tongue‐Like Bioactuator for Multidirectional Motion Through Directional Electrical Stimulation

Advanced Intelligent Systems, EarlyView.
A tongue‐like bioactuator is developed using orthogonally aligned cultured skeletal muscle tissues. By applying directional electrical stimulation of varying strengths, the actuator achieves jointless, multidirectional movements. The device features a fully soft, skeleton‐free design, enabling biomimetic deformation and functional actuation, and offers
Xuankai Gao, Kouhei Okasaki, Hirono Ohashi, Takeshi Sakurai, Yuya Morimoto   +4 more
wiley   +1 more source

Digital spatial profiling identifies features of primary and locoregional metastatic vasculature in triple negative breast cancer. [PDF]

Clin Exp Metastasis
Ravichandran A, Upton K, Taheri S, Liu C, Ferguson K, Adams M, Bray LJ.   +6 more
europepmc   +1 more source

Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1‐mediated macrophage polarization via the PI3K/Akt pathway

Animal Models and Experimental Medicine, EarlyView.
Transcriptome sequencing identified secreted phosphoprotein 1 (SPP1) as a crucial target through which methylophiopogonanone A (MOA) ameliorates pulmonary fibrosis. Molecular docking and microscale thermophoresis (MST) assays confirmed a favorable binding affinity between MOA and SPP1.
Fan Yang, Tian Li, Weiran Jia, Dingjie Xu, Liangdan Sun, Yanlei Ge, Yiwei Shi, Hong Xu, Xudong Song, Fuyu Jin, Na Mao   +10 more
wiley   +1 more source

Adult organotypic brain slice cultures recapitulate extracellular matrix remodeling in hemorrhagic stroke. [PDF]

Front Cell Neurosci
Hewitt BJ, Roberts L, Roberts JA, Fulton D, Hill LJ, Kitchen P, Bill RM, Botfield HF.   +7 more
europepmc   +1 more source

Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of RCHY1‐mediated P53 ubiquitination

Animal Models and Experimental Medicine, EarlyView.
Based on a dermis fibroblast Gorab knockout mouse model, this study revealed that Gorab deficiency promotes skin aging by influencing RCHY1, causing a decrease in P53 ubiquitination, damaging the activity of HDAC2, further resulting in the accumulation of aging‐related proteins (P53, P21, P16) and a reduction in extracellular matrix (ECM) components ...
Yanhong Li, Wei Liang, Yanfeng Xu, Yunlin Han, Wenjie Zhao, Siyuan Wang, Wei Deng, Chuan Qin   +7 more
wiley   +1 more source

A pilot study for decellularizing porcine cornea for future use in corneal regeneration. [PDF]

PLoS One
Josifovska N, Niemi EM, Ramalingam M, Manivasagam G, Scholz H, Petrovski G.   +5 more
europepmc   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Natural Isothiocyanates Block Adhesion and Invasion of Gemcitabine- and Cisplatin-Resistant Bladder Cancer Cell Lines. [PDF]

Molecules
Rutz J, Grein T, Laqua M, Benhassine K, Perktas E, Cinatl J, Thomas A, Chun FK, Haferkamp A, Juengel E, Tsaur I, Markowitsch SD, Blaheta RA.   +12 more
europepmc   +1 more source