Results 11 to 20 of about 333,512 (335)

Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway

Experimental Hematology & Oncology, 2023
Background Fibronectin, an extracellular matrix protein, has been reported to be associated with heterogeneous cancer stemness, angiogenesis and progression in multiple cancer types.
Fei Zhou, Jianguo Sun, Lingyun Ye, Tao Jiang, Wei Li, Chunxia Su, Shengxiang Ren, Fengying Wu, Caicun Zhou, Guanghui Gao   +9 more
doaj   +1 more source

Adhesion Characteristics of Human Pancreatic Islets, Duct Epithelial Cells, and Acinar Cells to a Polymer Scaffold

Cell Transplantation, 2022
We reported in 2018 that among several extracellular matrices, fibronectin, type I collagen, type IV collagen, laminin I, fibrinogen, and bovine serum albumin, fibronectin is particularly useful for adhesion of porcine pancreatic tissue. Subsequently, we
Yoshiki Nakashima, Hiroki Iguchi, Kenta Takakura, Yuta Nakamura, Kenji Izumi, Naoya Koba, Satoshi Haneda, Masayoshi Tsukahara   +7 more
doaj   +1 more source

Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-β. [PDF]

PLoS ONE, 2011
Fibrotic tissue in the liver is mainly composed of collagen. Fibronectin, which is also present in fibrotic matrices, is required for collagen matrix assembly in vitro. It also modulates the amount of growth factors and their release from the matrix.
Nina Kawelke, Matthaeus Vasel, Carla Sens, Anja von Au, Steven Dooley, Inaam A Nakchbandi   +5 more
doaj   +1 more source

Fibronectin glomerulopathy [PDF]

Clinical Kidney Journal, 2013
Fibronectin glomerulopathy occurs between the second and fifth decades of life in most patients, and it is known to be slowly progressive with mild proteinuria leading to kidney failure. The case of a 78-year-old woman with a rapid course of nephrotic syndrome due to fibronectin glomerulopathy is reported.
Ishimoto, Ikue, Sohara, Eisei, Ito, Eisaku, Okado, Tomokazu, Rai, Tatemitsu, Uchida, Shinichi   +5 more
openaire   +2 more sources

Engineered Biomimetic Fibrillar Fibronectin Matrices Regulate Cell Adhesion Initiation, Migration, and Proliferation via α5β1 Integrin and Syndecan‐4 Crosstalk

Advanced Science, 2023
Cells regulate adhesion to the fibrillar extracellular matrix (ECM) of which fibronectin is an essential component. However, most studies characterize cell adhesion to globular fibronectin substrates at time scales long after cells polarize and migrate ...
Seungkuk Ahn, Upnishad Sharma, Krishna Chaitanya Kasuba, Nico Strohmeyer, Daniel J. Müller   +4 more
doaj   +1 more source

The versatile roles of ADAM8 in cancer cell migration, mechanics, and extracellular matrix remodeling

Frontiers in Cell and Developmental Biology, 2023
The posttranslational proteolytic cleavage is a unique and irreversible process that governs the function and half-life of numerous proteins. Thereby the role of the family of A disintegrin and metalloproteases (ADAMs) plays a leading part.
Claudia Tanja Mierke
doaj   +1 more source

The evolution of tenascins and fibronectin [PDF]

Cell Adhesion & Migration, 2015
Tenascins are extracellular matrix glycoproteins that act both as integrin ligands and as modifiers of fibronectin-integrin interactions to regulate cell adhesion, migration, proliferation and differentiation. In tetrapods, both tenascins and fibronectin bind to integrins via RGD and LDV-type tripeptide motifs found in exposed loops in their ...
Adams, Josephine C, Chiquet-Ehrismann, Ruth, Tucker, Richard P   +2 more
openaire   +5 more sources

Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages

Journal of Neuroinflammation, 2018
Background Means to promote endogenous remyelination in multiple sclerosis (MS) benefit from insights into the role of inhibitory molecules that preclude remyelination.
Arend H. Sikkema, Josephine M. J. Stoffels, Peng Wang, Frederike J. Basedow, Robbert Bulsink, Jeffrey J. Bajramovic, Wia Baron   +6 more
doaj   +1 more source

Circulating Fibronectin Controls Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2013
Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation. The relative contribution of local and circulating fibronectin to blood vessel formation in vivo remains ...
Anja von Au, Matthaeus Vasel, Sabrina Kraft, Carla Sens, Norman Hackl, Alexander Marx, Philipp Stroebel, Jörg Hennenlotter, Tilman Todenhöfer, Arnulf Stenzl, Sarah Schott, Hans-Peter Sinn, Antoinette Wetterwald, Justo Lorenzo Bermejo, Marco G Cecchini, Inaam A Nakchbandi   +15 more
doaj   +1 more source

Cell surface localization of tissue transglutaminase is dependent on a fibronectin-binding site in its N-terminal beta-sandwich domain [PDF]

, 1999
Increasing evidence indicates that tissue transglutaminase (tTG) plays a role in the assembly and remodeling of extracellular matrices and promotes cell adhesion.
Aeschlimann, D, Cox, A, Gaudry, CA, Griffin, M, Smith, C, Verderio, E   +5 more
core   +1 more source