Results 41 to 50 of about 5,032 (112)

Interaction of integrin αvβ3 and fibronectin under fluid shear forces: implications for tumor cell adhesion and migration

Frontiers in Cell and Developmental Biology
The interaction between integrin αvβ3 and fibronectin enables tumor cell adherence to endothelial layers under diverse hydrodynamic blood flow conditions, particularly in low shear stress regions.
Paimin Zhuo, Quhuan Li, Bishan Yang, Bishan Yang, Na Li, Zhiqing Luo, Fengxia Zhang   +6 more
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Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

Frontiers in Physiology, 2014
In vascular smooth muscle cells (VSMC) increased integrin adhesion to extracellular matrix (ECM) proteins, as well as the production of reactive oxygen species (ROS) are strongly stimulated by lysophosphatidic acid (LPA). We hypothesized that LPA-induced
Marius C. Staiculescu, Francisco I. Ramirez-Perez, Francisco I. Ramirez-Perez, Jorge A. Castorena-Gonzalez, Jorge A. Castorena-Gonzalez, Zhongkui eHong, Zhe eSun, Gerald A. Meininger, Gerald A. Meininger, Gerald A. Meininger, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus, Luis A. Martinez-Lemus   +12 more
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Fibronectin Functionalized Electrospun Fibers by Using Benign Solvents: Best Way to Achieve Effective Functionalization

Frontiers in Bioengineering and Biotechnology, 2019
The aim of this study is to demonstrate the feasibility of different functionalization methods for electrospun fibers developed using benign solvents.
Liliana Liverani, Manuela S. Killian, Aldo R. Boccaccini   +2 more
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Modulation of fibronectin extracellular matrix enhances anti-tumor efficacy of immune checkpoint blockade

Cell Reports Medicine
Summary: The success of immune checkpoint inhibitors is limited by multiple factors, including poor T cell infiltration and function within tumors, partly due to a dense extracellular matrix (ECM).
Kabir A. Khan, Maresa Caunt Mitzner, William Cruz-Munoz, Grant Li, Patricia Himmels, Ping Xu, Hung Yang Kuo, Raj Jesudason, Alvin Gogineni, Robby Weimer, Annabelle Chow, Robert Piskol, Iacovos P. Michael, Weilan Ye, Robert S. Kerbel   +14 more
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Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac disease

Indian Journal of Pathology and Microbiology
Objectives: We hypothesized that crypt failure in the small bowel results in villous flattening in patients with celiac disease (CeD). We investigated whether alterations in the stem cell niche (ISC) are responsible for this phenomenon.
Prasenjit Das, Sudha Battu, Lalita Mehra, Alka Singh, Muzaffar Ahmad, Ashish Agarwal, Ashish Chauhan, Anam Ahmad, Sreenivas Vishnubhatla, Siddhartha Datta Gupta, Vineet Ahuja, Govind Makharia   +11 more
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Stimulation of Fibronectin Matrix Assembly by Lysine Acetylation

Cells, 2020
Diabetic nephropathy, a devastating consequence of diabetes mellitus, is characterized by the accumulation of extracellular matrix (ECM) that disrupts the kidney’s filtration apparatus. Elevated glucose levels increase the deposition of a fibronectin (FN)
Maria E. Vega, Birgit Kastberger, Bernhard Wehrle-Haller, Jean E. Schwarzbauer   +3 more
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Expression patterns of fibroblast activation protein and extra-domain B fibronectin in canine malignant tumors

Frontiers in Veterinary Science
IntroductionFibroblast activation protein (FAP) is involved in the extracellular matrix (ECM) remodeling and wound healing. Absent in most adult tissues, it is overexpressed by neoplastic cells and/or cancer-associated fibroblasts (CAFs) in several human
Silvia Dell’Aere, Elisa Maria Gariboldi, Alessandra Ubiali, Roberta Ferrari, Luigi Auletta, Matilde Bocci, Andrea Galbiati, Ettore Gilardoni, Giulia Rotta, Valentina Balbi, Gaia Beatrice Maria Bianchi, Alessandra Verdi, Dario Neri, Dario Neri, Samuele Cazzamalli, Damiano Stefanello, Paola Roccabianca   +16 more
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Molecular Dissection of the Campylobacter jejuni CadF and FlpA Virulence Proteins in Binding to Host Cell Fibronectin

Microorganisms, 2020
Campylobacter jejuni, a zoonotic pathogen that frequently colonizes poultry, possesses two Microbial Surface Components Recognizing Adhesive Matrix Molecule(s) (MSCRAMMs) termed CadF and FlpA that bind to the glycoprotein fibronectin (FN).
Prabhat K. Talukdar, Nicholas M. Negretti, Kyrah L. Turner, Michael E. Konkel   +3 more
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Ovarian cancer relies on the PDGFRβ–fibronectin axis for tumorsphere formation and metastatic spread

Molecular Oncology
High‐grade serous ovarian cancer (HGSOC) is the deadliest gynecological malignancy. The most common form of metastatic spread of HGSOC is transcoelomic dissemination.
Núria Gendrau‐Sanclemente, Agnès Figueras, Kristina Gracova, Álvaro Lahiguera, Elisenda Alsina‐Sanchís, Juan A. Marín‐Jiménez, August Vidal, Xavier Matias‐Guiu, Sergi Fernandez‐Gonzalez, Marc Barahona, Lola Martí, Jordi Ponce, Francesc Viñals   +12 more
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Co-culture of Umbilical Cord-derived Hematopoietic and Mesenchymal Stem Cells on Protein-Coated poly-L-Lactic Acid Nanoscaffolds

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Umbilical cord blood (UCB) is a source of Hematopoietic stem cells (HSCs) and has received a lot of attention due to its availability, renewal capacity, proliferation rate, and differentiation potential.
Maryam Islami, Masoud Soleimani, Monireh Ajami, Maryam Darvish   +3 more
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