Results 51 to 60 of about 201,822 (256)

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

open access: yesAdvanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam   +8 more
wiley   +1 more source

Fibronectin-Enriched Biomaterials, Biofunctionalization, and Proactivity: A Review

open access: yesApplied Sciences, 2021
Modern innovation in reconstructive medicine implies the proposition of material-based strategies suitable for tissue repair and regeneration. The development of such systems necessitates the design of advanced materials and the control of their ...
Carla Palomino-Durand   +2 more
doaj   +1 more source

Nanodiamond Sensing in Dynamic Environments With Fast‐Tracking Through Four‐Point Positioning

open access: yesAdvanced Functional Materials, EarlyView.
A four‐point positioning tracking (4PPT) platform enables fast 3D feedback translational tracking of fluorescent nanodiamonds while simultaneously recording ODMR spectra. By integrating real‐time translational tracking with quantum sensing, mobile nanodiamonds are used for in‐situ nanothermometry, nanorheometry, and 6D translation–rotation tracking in ...
Guoli Zhu   +10 more
wiley   +1 more source

Functional differences between two morphologically distinct cell subpopulations within a human colorectal carcinoma cell line

open access: yesBrazilian Journal of Medical and Biological Research, 2001
The LISP-I human colorectal adenocarcinoma cell line was isolated from a hepatic metastasis at the Ludwig Institute, São Paulo, SP, Brazil. The objective of the present study was to isolate morphologically different subpopulations within the LISP-I cell ...
A.C.C. Solimene   +3 more
doaj   +1 more source

PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake

open access: yesPharmaceutics, 2021
Tumor extracellular matrix (ECM) is a high-capacity target for the precision delivery of affinity ligand-guided drugs and imaging agents. Recently, we developed a PL1 peptide (sequence: PPRRGLIKLKTS) for systemic targeting of malignant ECM.
Prakash Lingasamy   +7 more
doaj   +1 more source

Bioinspired Co‐Assembly Enables Multiscale Architected Hydrogels for 3D Printing With Integrated Antibacterial and Bioactive Functions

open access: yesAdvanced Functional Materials, EarlyView.
A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov   +4 more
wiley   +1 more source

Fibronectin and Periostin as Prognostic Markers in Ovarian Cancer

open access: yesCells, 2020
Previously, based on a DNA microarray experiment, we identified a 96-gene prognostic signature associated with the shorter survival of ovarian cancer patients.
Katarzyna Aleksandra Kujawa   +5 more
doaj   +1 more source

CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway

open access: yesmBio, 2023
Epithelial colonization is a critical first step in bacterial pathogenesis. Staphylococcus aureus can utilize several host factors to associate with cells, including α5β1 integrin and heparan sulfate proteoglycans, such as the syndecans.
Luke R. Green   +9 more
doaj   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

open access: yesAdvanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro   +25 more
wiley   +1 more source

Hierarchical Collagen Nanofiber Gels Recapitulate a Physiologically Relevant Tumor Stromal Microenvironment

open access: yesAdvanced Healthcare Materials, EarlyView.
The collagen nanofiber (CNF) gel supports cancer cell culture, exhibiting cell morphology and cancer‐related protein expression similar to Matrigel. It offers a higher collagen concentration than commercial gels. Additionally, the CNF gel allows replication of the high elasticity of in vivo cancer tissue by controlling collagen fiber sizes, ranging ...
Naoko Sasaki   +4 more
wiley   +1 more source

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