Results 141 to 150 of about 8,122 (251)

Increase of VEGF and Fibronectin expression and ultrastructural alterations of intercellular junctions in a swab negative patient after SARS-COV-2 infection. [PDF]

Virol J
Simioni C, Sanz JM, Gafà R, Cenacchi G, Occhionorelli S, Passaro A, Neri LM.   +6 more
europepmc   +1 more source

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

CuATSM effectively ameliorates ALS patient astrocyte‐mediated motor neuron toxicity in human in vitro models of amyotrophic lateral sclerosis

Glia, Volume 71, Issue 2, Page 350-365, February 2023., 2023
Main Points The clinical stage drug CuATSM normalizes aberrant metabolic phenotypes of ALS astrocytes and restores support towards neurons. Patient samples could be stratified based on this phenotype, indicating that the model system might support clinical trial result interpretation or design.
Cassandra N. Dennys, Florence Roussel, Rochelle Rodrigo, Xiaojin Zhang, Andrea Sierra Delgado, Annalisa Hartlaub, Asya Saelim‐Ector, Will Ray, Sarah Heintzman, Ashley Fox, Stephen J. Kolb, Joseph Beckman, Maria Clara Franco, Kathrin Meyer   +13 more
wiley   +1 more source

Cryogenic, but not hypothermic, preservation disrupts the extracellular matrix of cell sheets. [PDF]

Bioact Mater
Freitas-Ribeiro S, Carvalho AF, Rodrigues DB, Martins L, Pires RA, Mendes VM, Manadas B, Jarnalo M, Horta R, Reis RL, Pirraco RP.   +10 more
europepmc   +1 more source

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Retinal regions shape human and murine Müller cell proteome profile and functionality

Glia, Volume 71, Issue 2, Page 391-414, February 2023., 2023
Main Points We defined Müller cells heterogeneity in the macular and peripheral human retina. Signaling pathways shaping this glial heterogeneity include proteins important for interaction with vesicular secretion, extracellular matrix and cell adhesion.
Lew Kaplan, Corinne Drexler, Anna M. Pfaller, Santra Brenna, Kirsten A. Wunderlich, Andrea Dimitracopoulos, Juliane Merl‐Pham, Maria‐Theresa Perez, Ursula Schlötzer‐Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M. Hauck, Antje Grosche   +15 more
wiley   +1 more source

Development and characterization of a novel injectable thyroid extracellular matrix hydrogel for enhanced thyroid tissue engineering applications. [PDF]

Front Bioeng Biotechnol
Zhang L, Long H, Zhang P, Liu B, Li S, Sun R, Diao T, Li F.   +7 more
europepmc   +1 more source

Efficient Generation of Megakaryocyte Progenitors and Platelets From HSPCs via JAK2/STAT3 Signaling

Advanced Science, EarlyView.
This research presents a novel strategy employing the VGM cocktail, which combines HES7 overexpression with HDAC inhibitor and GABA, to enhance platelet production from hematopoietic stem and progenitor cells by promoting megakaryocyte progenitor (MkP) generation.
Huicong Liu, Lingna Wang, Jiaqing Liu, Haitao Yuan, Kaiqing Zhang, Yun Qiu, Fangfang Zhu   +6 more
wiley   +1 more source

Emerging Therapeutic Options in Pancreatic Cancer Management. [PDF]

Int J Mol Sci
Delle Cave D.
europepmc   +1 more source

Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions

Advanced Science, EarlyView.
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian   +11 more
wiley   +1 more source