Results 281 to 290 of about 86,137 (348)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Staphylococcal internalization into osteoblasts: a partially conserved mechanism across the genus. [PDF]

mBio
Crepin DM, Bonhomme M, Faure A, Sinel C, Bergot M, Dyon-Tafani V, Maali Y, Bouvard D, Diot A, Laurent F, Josse J.   +10 more
europepmc   +1 more source

Pearl‐Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced Science, EarlyView.
In this study, inspired by pearl architecture, we developed a layered Ca–P “brick” and Fn‐mimetic peptide “mortar” coating on Mg alloys. The Ca–P layer moderates corrosion and offers mineral cues, while the peptide enhances adhesion and regulates immune‐vascular responses.
Siming Zhang, Tao Zhang, Yuan Chen, Nikolaos Kourkoumelis, Mo Chen, Jiale Dong, Zhenyu Li, Yanling Zhou, Ning Li, Chen Zhu, Xifu Shang, Jiaxiang Bai, Xianzuo Zhang   +12 more
wiley   +1 more source

Irisin and adropin decrease in preobese or obese individuals with nonalcoholic fatty liver disease. [PDF]

Turk J Med Sci
Mertoğlu C, Örek YŞ, Albayrak B, Arslan YK, Çoban A.   +4 more
europepmc   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Molecular Mechanisms of Lymph Node Metastasis in Gallbladder Cancer: Insights into the Tumor Microenvironment. [PDF]

Biomedicines
Tang Q, Guan Y, Ma Y, Li Q, Geng Z.
europepmc   +1 more source

Jointless Tongue‐Like Bioactuator for Multidirectional Motion Through Directional Electrical Stimulation

Advanced Intelligent Systems, EarlyView.
A tongue‐like bioactuator is developed using orthogonally aligned cultured skeletal muscle tissues. By applying directional electrical stimulation of varying strengths, the actuator achieves jointless, multidirectional movements. The device features a fully soft, skeleton‐free design, enabling biomimetic deformation and functional actuation, and offers
Xuankai Gao, Kouhei Okasaki, Hirono Ohashi, Takeshi Sakurai, Yuya Morimoto   +4 more
wiley   +1 more source

Circulating organokines in coronary artery disease and metabolic syndrome: FABP4, adiponectin, irisin, FSTL1. [PDF]

Biomol Biomed
Uyaner Kan M, Kilinc İ, Akilli H, Bilgic HH.   +3 more
europepmc   +1 more source

Recent advances in animal models for pathological scar research: A comprehensive review of experimental approaches and translational relevance

Animal Models and Experimental Medicine, EarlyView.
Animal models remain indispensable in the study of pathological scars, each offering unique advantages and constraints. Their integration with in vitro and ex vivo systems is key to developing personalized, clinically translatable antifibrotic therapies. Abstract Pathological scarring, manifested in the form of hypertrophic scars (HTS) and keloid scars
Diana‐Larisa Ancuța, Mariana Văduva, Cristin Coman, Iuliana Caraș   +3 more
wiley   +1 more source

DIRAS3 Inhibits Ovarian Cancer Cell Growth by Blocking the Fibronectin-Mediated Integrin β1/FAK/AKT Signaling Pathway. [PDF]

Cells
Guo J, Santiago-O'Farrill JM, Orellana V, Ozyurt R, Yang H, Pina M, Bildik G, Mao W, Bast RC, Lu Z.   +9 more
europepmc   +1 more source