Results 51 to 60 of about 94,496 (352)

Expression and function of alpha(v)beta(3) and alpha(v)beta(5) integrins in the developing pancreas: roles in the adhesion and migration of putative endocrine progenitor cells. [PDF]

, 2000
Cell-cell and cell-matrix interactions play a critical role in tissue morphogenesis and in homeostasis of adult tissues. The integrin family of adhesion receptors regulates cellular interactions with the extracellular matrix, which provides three ...
Alpert, Bauer, Beattie, Beattie, Beattie, Blaschuk, Bosco, Brooks, Brooks, Calof, Cheng, Choquet, Cirulli, Cirulli, Cirulli, Clark, Clark, Dahl, DiPersio, Drake, Dudek, Ekblom, Felding-Habermann, Friedlander, George, Giancotti, Gu, Gu, Gullberg, Herrera, Herrera, Hynes, Hynes, Jaffe, Jansson, Jensen, Jones, Kantengwa, Langerhans, Langhofer, Like, Lin, Lombardi, Marchisio, Orci, Orci, Orci, Otonkoski, Otonkoski, Otonkoski, Pelletier, Pictet, Pictet, Pierschbacher, Ricordi, Rouiller, Sandler, Schwartz, Slack, Sonnenberg, Stefan, Strange, Talhouk, Teitelman, Tuch, Von Dorsche, Walker, Watt   +67 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Triglycerides Predict Plasma Fibronectin in Children with Type I Diabetes Mellitus Rather than Diabetes

Acta Medica, 2002
Fibronectins are adhesive proteins considered as markers of endothelial activation. Plasma fibronectin levels in diabetes mellitus (DM) have been found to be associated with atherosclerotic risk factors.
Ayşe Binnur Erbağcı, Mehmet Tarakçıoğlu, Ahmet Erbağcı, Mehmet Gözübüyük, Necat Yılmaz, Rukiye Deveci, Ramazan Kocabaş   +6 more
doaj   +1 more source

Fibronectin and Fibronectin Receptors in Lung Development

Experimental Lung Research, 1997
Fibronectin (FN) is a cell adhesive extracellular matrix protein highly expressed in developing lungs. Although the role of FN in lung development remains to be elucidated, several observations suggest that it plays important roles in many developmental processes. In vitro, FN can affect the migration, proliferation, differentiation, and even apoptosis
openaire   +2 more sources

Structural comparison of fibronectins from normal and transformed cells.

Journal of Biological Chemistry, 1981
Comparative study of the structures of fibronectins from normal and transformed cells by partial proteolysis as well as by tryptic peptide fingerprinting and analysis of phosphorylation show that: 1) fibronectin molecules from normal and transformed ...
I. Ali, T. Hunter
semanticscholar   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Detection of Fibronectin-Binding Proteins in Clostridium perfringens. [PDF]

, 2006
Clostridium perfringens is an anaerobic spore-forming pathogen of humans and animals. C. perfringens type A strains, 13, CPN50, and NCTC8237, isolated from human gas gangrene, bound specifically to human fi bronectin (Fn).
Hitsumoto, Yasuo, Katayama, Seiichi, Nozu, Nanami, Yokoyama, Masako   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy.

PLoS ONE, 2016
Liver sinusoidal endothelial cells (LSECs) are the main endothelial cells in the liver and are important for maintaining liver homeostasis as well as responding to injury.
Bridget Sackey-Aboagye, Abby L Olsen, Sarmistha M Mukherjee, Alexander Ventriglia, Yasuyuki Yokosaki, Linda E Greenbaum, Gi Yun Lee, Hani Naga, Rebecca G Wells   +8 more
doaj   +1 more source