Results 41 to 50 of about 9,243 (229)

Fibronectin's tensional state as a mechanical signature of fibrotic extracellular matrix in idiopathic pulmonary fibrosis models

Matrix Biology Plus
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with limited treatment options. Emerging evidence suggests that the composition and mechanics of the extracellular matrix (ECM) play a crucial role in IPF pathogenesis; however ...
Konstantin M.P. Wolf, Emmanouil Angelidakis, Daria Künzli, David Lauer, Matthias Brunner, Alessia Cambria, Divya Vats, Britta Maurer, Viola Vogel, Mamta Chabria   +9 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Structural and functional comparisons of chicken and human cellular fibronectins

, 1984
We have investigated the structural and functional differences between chicken and human cellular fibronectin (i) by comparing the tryptic peptide patterns using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (ii) by analyzing the binding ...
Yamada, K. M., Newton, S. A., Bernard, B. A., Akiyama, S. K., Olden, K.   +4 more
core   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Immunohistochemical localization of fibronectin as a tool for the age determination of human skin wounds [PDF]

, 1992
We analyzed the distribution of fibronectin in routinely embedded tissue specimens from 53 skin wounds and 6 postmortem wounds. In postmortem wounds a faint but focal positive staining was exclusively found at the margin of the specimens which dit not ...
Penning, R., Eisenmenger, Wolfgang, J. Tübel, J. Wilskel, A. Nerlich, W. Eisenmenger, Tübel, J., Wilske, J., Wiest, I., R. Penning, Nerlich, A., I. Wiest, P. Betz, Betz, P.   +13 more
core   +1 more source

Bioinspired Co‐Assembly Enables Multiscale Architected Hydrogels for 3D Printing With Integrated Antibacterial and Bioactive Functions

Advanced Functional Materials, EarlyView.
A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov, Francesca Netti, Sigal Rencus‐Lazar, Moran Aviv, Lihi Adler‐Abramovich   +4 more
wiley   +1 more source

Indicadores de risco para o parto prematuro Risk predictors for preterm birth

Revista Brasileira de Ginecologia e Obstetrícia, 2009
Entre os vários fatores clínicos para o parto prematuro, alguns apresentam riscos substanciais, tais como história de parto prematuro, gemelidade e sangramento vaginal do segundo trimestre. No entanto, tais fatores estão presentes na minoria das mulheres
Roberto Eduardo Bittar, Marcelo Zugaib
doaj   +1 more source

Reversible Tuning of Multiple Molecular Kinking for Stem Cell Regulation In Vivo

Advanced Functional Materials, EarlyView.
In this work, we introduce the novel concept of background component‐free “multiple kinks” material platform composed solely of liganded multiple kink‐bearing molecules as a strategy for dynamic biomaterial design. Tri‐kink molecules enable effective near‐infrared light‐triggered ligand masking and visible light‐triggered ligand exposure, thereby ...
Kanghyeon Kim, Jeongah Shin, Chowon Kim, Honghwan Choi, Dahee Kim, Sungkyu Lee, Choongmo Kang, Hyunsik Hong, Taehoon Ha, Nayeon Kang, Jungyeon Rhi, Ramar Thangam, Yuri Kim, Jeongyun Heo, Cheol Hwan Kwak, Jangsun Hwang, Daun Jeong, Rasoul Moradi, Sunghoon Hur, Hyun‐Cheol Song, Hyun‐Do Jung, Min Jae Lee, Rongqin Huang, Pooyan Makvandi, Yun Suk Huh, Ji Hye Choi, Wenguo Cui, Sehoon Kim, Heemin Kang   +28 more
wiley   +1 more source

Differences in domain structure between human fibronectins isolated from plasma and from culture supernatants of normal and transformed fibroblasts : Studies with domain-specific antibodies [PDF]

, 1985
This research was originally published in the Journal of Biological Chemistry. K Sekiguchi, A Siri, L Zardi and S Hakomori. Differences in domain structure between human fibronectins isolated from plasma and from culture supernatants of normal and ...
Zardi, Luciano, Hakomori, Sen-itiroh, Siri, Annalisa, Sekiguchi, Kiyotoshi   +3 more
core   +1 more source

Embryonic fibronectins are up‐regulated following peripheral nerve injury in rats

, 1995
Fibronectin mRNAs that include the alternatively spliced exons EIIIA, EIIIB, and V are prevalent during embryogenesis, and EIIIA and EIIIB reappear during wound healing.
ffrench-Constant, Charles, Mathews, Greta A.   +1 more
core   +1 more source