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Fibronectin and Its Receptors in Hematopoiesis [PDF]

open access: yesCells, 2020
Fibronectin is a ubiquitous extracellular matrix protein that is produced by many cell types in the bone marrow and distributed throughout it. Cells of the stem cell niche produce the various isoforms of this protein.
Franziska Wirth   +3 more
doaj   +4 more sources

Fibronectin and Fibronectin Receptors in Lung Development

open access: yesExperimental Lung Research, 1997
Fibronectin (FN) is a cell adhesive extracellular matrix protein highly expressed in developing lungs. Although the role of FN in lung development remains to be elucidated, several observations suggest that it plays important roles in many developmental processes. In vitro, FN can affect the migration, proliferation, differentiation, and even apoptosis
Jesse Roman
exaly   +3 more sources

Structural and transcriptomic alterations underlying the progression of aortic dissection in Fbn1 G234D/G234D mice [PDF]

open access: yesScientific Reports
Aortic dissection (AD) is characterized by separation within the medial layers of the aortic wall. Pathogenic variants in the fibrillin-1 gene (FBN1), which cause Marfan syndrome, represent a major genetic cause of AD.
Md Al Amin Sheikh   +16 more
doaj   +2 more sources

Aligned Fibronectin Microenvironment Temporally Facilitates Profibrotic Fibroblast Activation via Integrin α5β1 [PDF]

open access: yesAdvanced Science
Excessive, aligned nanofibrous extracellular matrix deposition is a main feature of fibrosis, a pathology indicative of poor prognosis in various chronic diseases.
Doğuhan Beyatlı   +3 more
doaj   +2 more sources

Fibronectin Functions as a Selective Agonist for Distinct Toll-like Receptors in Triple-Negative Breast Cancer

open access: yesCells, 2022
The microenvironment of tumors is characterized by structural changes in the fibronectin matrix, which include increased deposition of the EDA isoform of fibronectin and the unfolding of the fibronectin Type III domains.
Anthony Ambesi   +2 more
doaj   +1 more source

Conformational changes of exogenous deposited fibronectin on decellularized aortic conduits after implantation

open access: yesVietnam Journal of Science, Technology and Engineering, 2022
Fibronectin is an abundant and ubiquitous extracellular matrix component that regulates a wide range of cell functions by directly interacting with cell surface integrin receptors.
Khon Huynh
doaj   +1 more source

CTLs From Patients With Atherosclerosis Show Elevated Adhesiveness and Distinct Integrin Expression Patterns on 2D Substrates

open access: yesFrontiers in Medicine, 2022
Atherosclerosis is the major cause of cardiovascular disease that is characterized by plaque formation in the blood vessel wall. Atherosclerotic plaques represent sites of chronic inflammation with diverse cell content that is shifted toward the ...
Daria M. Potashnikova   +9 more
doaj   +1 more source

Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity

open access: yeseLife, 2021
Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of ...
Jacopo Di Russo   +5 more
doaj   +1 more source

Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. [PDF]

open access: yesPLoS ONE, 2008
Fibronectin polymerization is essential for the development and repair of the extracellular matrix. Consequently, deciphering the mechanism of fibronectin fibril formation is of immense interest.
Elaine P S Gee   +2 more
doaj   +1 more source

Circulating fibronectin and fibronectin receptor in children with pertussis. [PDF]

open access: yesJournal of Clinical Pathology, 1994
AIM--To determine concentrations of fibronectin and fibronectin receptor in children with pertussis. METHODS--Concentrations of circulating fibronectin and serum fibronectin receptor were detected in eight children affected by pertussis, eight children with acute upper or lower respiratory tract infections, and in 14 healthy control children.
D, Torre   +5 more
openaire   +2 more sources

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