Results 1 to 10 of about 91,178 (265)

Fibronectin and Its Receptors in Hematopoiesis [PDF]

Cells, 2020
Fibronectin is a ubiquitous extracellular matrix protein that is produced by many cell types in the bone marrow and distributed throughout it. Cells of the stem cell niche produce the various isoforms of this protein.
Franziska Wirth, Alexander Lubosch, Stefan Hamelmann, Inaam A. Nakchbandi   +3 more
doaj   +4 more sources

Structural and transcriptomic alterations underlying the progression of aortic dissection in Fbn1 G234D/G234D mice [PDF]

Scientific Reports
Aortic dissection (AD) is characterized by separation within the medial layers of the aortic wall. Pathogenic variants in the fibrillin-1 gene (FBN1), which cause Marfan syndrome, represent a major genetic cause of AD.
Md Al Amin Sheikh, Kenichi Kimura, Eri Motoyama, Keiichi Asano, Violette Deleeuw, Patrick Sips, Chiho Tokunaga, Hiroko Matsunaga, Sachiko Kanki, Shigeki Koizumi, Kaori Sugiyama, Julie De Backer, Lynn Y. Sakai, Haruko Takeyama, Yuji Hiramatsu, Haruka Ozaki, Hiromi Yanagisawa   +16 more
doaj   +2 more sources

Aligned Fibronectin Microenvironment Temporally Facilitates Profibrotic Fibroblast Activation via Integrin α5β1 [PDF]

Advanced Science
Excessive, aligned nanofibrous extracellular matrix deposition is a main feature of fibrosis, a pathology indicative of poor prognosis in various chronic diseases.
Doğuhan Beyatlı, Mika Brown, George‐Radu Romanescu, Seungkuk Ahn   +3 more
doaj   +2 more sources

Fibronectin Functions as a Selective Agonist for Distinct Toll-like Receptors in Triple-Negative Breast Cancer

Cells, 2022
The microenvironment of tumors is characterized by structural changes in the fibronectin matrix, which include increased deposition of the EDA isoform of fibronectin and the unfolding of the fibronectin Type III domains.
Anthony Ambesi, Pranav Maddali, Paula J. McKeown-Longo   +2 more
doaj   +1 more source

Conformational changes of exogenous deposited fibronectin on decellularized aortic conduits after implantation

Vietnam Journal of Science, Technology and Engineering, 2022
Fibronectin is an abundant and ubiquitous extracellular matrix component that regulates a wide range of cell functions by directly interacting with cell surface integrin receptors.
Khon Huynh
doaj   +1 more source

CTLs From Patients With Atherosclerosis Show Elevated Adhesiveness and Distinct Integrin Expression Patterns on 2D Substrates

Frontiers in Medicine, 2022
Atherosclerosis is the major cause of cardiovascular disease that is characterized by plaque formation in the blood vessel wall. Atherosclerotic plaques represent sites of chronic inflammation with diverse cell content that is shifted toward the ...
Daria M. Potashnikova, Daria M. Potashnikova, Aleena A. Saidova, Anna V. Tvorogova, Alexandra S. Anisimova, Alexandra S. Anisimova, Alexandra Yu Botsina, Elena Yu Vasilieva, Elena Yu Vasilieva, Leonid B. Margolis   +9 more
doaj   +1 more source

Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity

eLife, 2021
Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of ...
Jacopo Di Russo, Jennifer L Young, Julian WR Wegner, Timmy Steins, Horst Kessler, Joachim P Spatz   +5 more
doaj   +1 more source

Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. [PDF]

PLoS ONE, 2008
Fibronectin polymerization is essential for the development and repair of the extracellular matrix. Consequently, deciphering the mechanism of fibronectin fibril formation is of immense interest.
Elaine P S Gee, Donald E Ingber, Collin M Stultz   +2 more
doaj   +1 more source

Wnt5A modulates integrin expression in a receptor-dependent manner in ovarian cancer cells

Scientific Reports, 2021
Wnt5A signals through various receptors that confer versatile biological functions. Here, we used Wnt5A overexpressing human ovarian SKOV-3 and OVCAR-3 stable clones for assessing integrin expression, cell proliferation, migration, invasion, and the ...
Vajihe Azimian-Zavareh, Zeinab Dehghani-Ghobadi, Marzieh Ebrahimi, Kian Mirzazadeh, Irina Nazarenko, Ghamartaj Hossein   +5 more
doaj   +1 more source

The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. [PDF]

PLoS ONE, 2013
BACKGROUND: In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by
Michael Roth, Jun Zhong, Celine Zumkeller, Chong Teck S'ng, Stephanie Goulet, Michael Tamm   +5 more
doaj   +1 more source