PLoS ONE, 2015 Therapeutic angiogenesis may be applied in medical conditions to promote stimulation of angiogenesis. Angiogenesis is a multistep process, which includes endothelial cell proliferation, migration, and tube formation, which is mediated by various ...
Iana Mayane Mendes Nicácio Viana +5 more
doaj +1 more source
Modulation of cell-matrix adhesions to affect mechanotransduction [PDF]
, 2010 In cultured fibroblasts three types of cell-matrix adhesion with specific cellular localization and protein composition can be distinguished: focal complexes, focal adhesions and fibrillar adhesions.
Lutz, Roman
core +1 more source
The integrin-ligand interaction regulates adhesion and migration through a molecular clutch. [PDF]
PLoS ONE, 2012 Adhesive and migratory behavior can be cell type, integrin, and substrate dependent. We have compared integrin and substrate differences using three integrin receptors: α5β1, α6β1, and αLβ2 expressed in a common cell type, CHO.B2 cells, which lack ...
Lingfeng Chen +4 more
doaj +1 more source
Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling. [PDF]
, 2011 Autoimmune uveitis is an intraocular inflammation that arises through autoreactive T-cells attacking the inner eye, eventually leading to blindness. However, the contributing molecular pathomechanisms within the affected tissues remain as yet elusive ...
Cornelia A. Deeg +21 more
core +2 more sources
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys Peptides on Mg-Doped Hydroxyapatite
Engineering, 2017 Stem cell homing, namely the recruitment of mesenchymal stem cells (MSCs) to injured tissues, is highly effective for bone regeneration in vivo. In order to explore whether the incorporation of mimetic peptide sequences on magnesium-doped (Mg-doped ...
Alessandro Pistone +7 more
doaj +1 more source
Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway
Cell Adhesion & Migration, 2020 A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors.
Joanna Pastwińska +4 more
doaj +1 more source
Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2 [PDF]
, 2002 In the present study we investigated the role of the fibronectin (FN)- and fibrinogen (FGN)-binding protein (FBPS) in the pathogenesis of Streptococcus suis serotype 2 in piglets. The complete gene encoding FBPS from S.
Dijkstra, J. +11 more
core +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Fibronectin receptors (integrin) in corneal epithelial wound healing [PDF]
, 1992 Fibronectin has been reported to play an essential role in the attachment and migration of the corneal epithelial cells and has been successfully applied for the treatment of non-healing corneal epithelial disorders.
村上, 純子, Murakami, Junko
core +1 more source