Results 51 to 60 of about 665,801 (246)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Advanced ScienceExcessive, aligned nanofibrous extracellular matrix deposition is a main feature of fibrosis, a pathology indicative of poor prognosis in various chronic diseases.
Doğuhan Beyatlı +3 more
doaj +1 more source
Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
Cells, 2019 The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells.
Selene Pérez-García +9 more
doaj +1 more source
Fibronectin Matrix Deposition and Fibronectin Receptor Expression in Healing and Normal Skin [PDF]
, 1990 During cutaneous tissue organization, numerous critical interactions occur between cells and the extracellular matrix (ECM). Cell-matrix interactions depend on the presence of ECM receptors.
Richard A F Clark, Clark, Richard A F
core +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Mouse basophils reside in extracellular matrix-enriched bone marrow niches which control their motility. [PDF]
PLoS ONE, 2013 Basophils co-express FcεRIα and CD49b, the α-2 chain of integrin-type receptor VLA-2 (α2β1), which recognizes type-1 collagen as a major natural ligand.
Salete Smaniotto +7 more
doaj +1 more source
Real-Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids. [PDF]
Adv Sci (Weinh)This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Incaviglia I +8 more
europepmc +2 more sources
Characterization of tenascin-C-induced signaling in tumorigenesis [PDF]
, 2008 During cancer progression, the extracellular matrix (ECM) is extensively remodeled. The ECM molecule tenascin-C is an adhesion-modulating molecule, which is highly expressed in tumor stroma.
Lange, Katrin
core +1 more source
Advanced Functional Materials, EarlyView.A multicomponent supramolecular hydrogel integrating cell‐adhesive and antibacterial peptides within an alginate‐cellulose nanofibril matrix is developed. Peptide co‐assembly simultaneously strengthens the hydrogel network, improves extrusion printability, and imparts cell‐adhesive and antibacterial functions, offering a versatile platform for ...
Mor Tsuriano‐Zernichov +4 more
wiley +1 more source
Dioscorea alata attenuates renal interstitial cellular fibrosis by regulating Smad- and epithelial-mesenchymal transition signaling pathways. [PDF]
PLoS ONE, 2012 Renal interstitial fibrosis is characterized by increased extracellular matrix (ECM) synthesis. Epithelial-mesenchymal transition (EMT) in kidneys is driven by regulated expression of fibrogenic cytokines such as transforming growth factor-beta (TGF-β ...
Shu-Fen Liu +10 more
doaj +1 more source