Results 61 to 70 of about 94,496 (352)

Neural crest cell-autonomous roles of fibronectin in cardiovascular development. [PDF]

, 2015
The chemical and mechanical properties of extracellular matrices (ECMs) modulate diverse aspects of cellular fates; however, how regional heterogeneity in ECM composition regulates developmental programs is not well understood.
Astrof, Sophie, Wang, Xia
core   +2 more sources

Susceptibility of soluble and matrix fibronectins to degradation by tissue proteinases, mast cell chymase and cathepsin G.

Journal of Biological Chemistry, 1981
Fibronectin is a glycoprotein present in soluble form in plasma and other body fluids and in insoluble form in extracellular matrix. We have studied the effect of two neutral tissue proteinases, rat mast cell chymase and the closely related human ...
T. Vartio, H. Seppä, A. Vaheri
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Fibroblast-like synovial cell production of extra domain A fibronectin associates with inflammation in osteoarthritis

BMC Rheumatology, 2019
Background The pathophysiology of osteoarthritis (OA) involves wear and tear, and a state of low-grade inflammation. Tissue repair responses include transforming growth factor beta (TGFβ)-induced myofibroblast production of extracellular matrix ...
Tue W. Kragstrup, Dong H. Sohn, Christin M. Lepus, Kazuhiro Onuma, Qian Wang, William H. Robinson, Jeremy Sokolove   +6 more
doaj   +1 more source

Live Imaging of Type I Collagen Assembly Dynamics in Osteoblasts Stably Expressing GFP and mCherry-Tagged Collagen Constructs [PDF]

, 2018
Type I collagen is the most abundant extracellular matrix protein in bone and other connective tissues and plays key roles in normal and pathological bone formation as well as in connective tissue disorders and fibrosis.
Bonewald, Lynda F., Dallas, Sarah L., Dusevich, Vladimir, Grillo, Michael A., Kamel-El Sayed, Suzan A., Lu, Yongbo, Phillips, Charlotte L., Tiede-Lewis, LeAnn M., Veno, Patricia A., Wang, Kun   +9 more
core   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Functional dissection of the Drosophila Kallmann's syndrome protein DmKal-1

BMC Genetics, 2006
Background Anosmin-1, the protein implicated in the X-linked Kallmann's syndrome, plays a role in axon outgrowth and branching but also in epithelial morphogenesis. The molecular mechanism of its action is, however, widely unknown.
Panetta Vittorio, Grimaldi Maria R, Andrenacci Davide, Riano Elena, Rugarli Elena I, Graziani Franco   +5 more
doaj   +1 more source

Immunohistochemical localization of fibronectin as a tool for the age determination of human skin wounds [PDF]

, 1992
We analyzed the distribution of fibronectin in routinely embedded tissue specimens from 53 skin wounds and 6 postmortem wounds. In postmortem wounds a faint but focal positive staining was exclusively found at the margin of the specimens which dit not ...
A Nerlich, A Vaheri, A. Nerlich, AE Postlethwaite, DF Mosher, E Boehm, E Linder, E Ruoslahti, E Ruoslahti, EA Jaffee, F Grinnell, F Grinnell, F Jilek, H Hormann, H Hormann, I. Wiest, J Raekallio, J Raekallio, J Viljanto, J. Tübel, J. Wilskel, K Alitalo, KM Yamada, LA Repesh, M Kurkinen, M Oehmichen, M Oehmichen, MW Mosesson, P Betz, P Davison, P. Betz, R Jarecki, R. Penning, RAF Clark, RAF Clark, S Berg, S Berg, S Berg, S Stenman, SM Hsu, St Niewiarowski, V Schneider, W Eisenmenger, W. Eisenmenger   +43 more
core   +1 more source

Domain-specific distribution of carbohydrates in human fibronectins and the transformation-dependent translocation of branched type 2 chain defined by monoclonal antibody C6.

Journal of Biological Chemistry, 1986
Fibronectins purified from human plasma (termed pFN), spent culture media of human fibroblasts WI38 (termed cFN), and SV40 virus-transformed WI38/VA13 cells (termed tFN) and their cleavage fragments were compared with respect to their binding activities ...
E. Nichols, B. Fenderson, W. Carter, S. Hakomori   +3 more
semanticscholar   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source