Results 51 to 60 of about 65,201 (219)

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Moléculas moduladoras de vías de señalización basales y desencadenadas por el Factor de Crecimiento Derivado de Plaquetas (PDGF) en un modelo celular de fibrosarcoma humano

Revista de Nutrición Clínica y Metabolismo, 2018
La sobreexpresión del Factor de Crecimiento Derivado de Plaquetas (PDGF) y sus receptores ha sido relacionada con el desarrollo de patologías asociadas a la pérdida del control de la proliferación, como el cáncer, principalmente sarcomas de tejidos ...
Adriana Grismaldo, Ludis Morales
doaj   +1 more source

Isolation, spectroscopic characterization, X-ray, theoretical studies as well as in vitro cytotoxicity of Samarcandin [PDF]

, 2016
Samarcandin 1, a natural sesquiterpene-coumarin, was isolated as well as elucidated from F. assa-foetida which has significant effect in Iranian traditional medicine because of its medicinal attitudes.
Atabaki, V., Babaei, E., Dusek, M., Eigner, V., Ghoran, S.H., Khalaji, A.D., Olfatkhah, S.R., Soltani, A.   +7 more
core   +1 more source

Real‐Time, Label‐Free Classification of Cell Death Pathways via Holotomography‐Based Deep Learning Framework

Advanced Intelligent Systems, EarlyView.
A 3D holotomography system coupled with a deep learning model distinguishes how cells die—apoptosis, necroptosis or necrosis—without any fluorescent labels. Training on refractive index maps of HeLa cells yields 97% accuracy and flags necroptosis hours before chemical dyes.
Minwook Kim, Wei Sun Park, Geon Kim, Sanggeun Oh, Jaephil Do, Juyeon Park, Jihwan Yu, Won Do Heo, YongKeun Park   +8 more
wiley   +1 more source

Genetically engineered GSDME vesicle coated nanoparticle for immune activating and pyroptosis inducing synergetic therapy of fibrosarcoma

Materials Today Bio
Fibrosarcoma is a kind of highly malignant sarcoma with high recurrence rate after surgery and unsatisfying efficacy of radiotherapy and chemotherapy. Increasing the concentration of gasdermin in tumor cell to induce pyroptosis is a promising strategy to
Fenglin Miao, Zhao Wang, Qing Wang, Changsheng Zhou, Xiao Zhou, Jialiang Zheng, Yuan Ma, Zhenhang Lin, Yilai Gao, Ting Wu, Yong Zhang, Jing Gao, Wengang Li   +12 more
doaj   +1 more source

Two simple-to-use web-based nomograms to predict overall survival and cancer-specific survival in patients with extremity fibrosarcoma

Frontiers in Oncology, 2023
BackgroundFibrosarcoma is a rare sarcoma of the soft tissue in adults, occurring most commonly in the extremities. This study aimed to construct two web-based nomograms to predict overall survival (OS) and cancer-specific survival (CSS) in patients with ...
Yubo Li, Jianing Yang, Long Zhao, Bin Chen, Yongsheng An   +4 more
doaj   +1 more source

Possible immunoenhancement of persistent viremia by feline leukemia virus envelope glycoprotein vaccines in challenge-exposure situations where whole inactivated virus vaccines were protective. [PDF]

, 1986
Kittens immunized with purified native FeLV-gp70 or -gp85 envelope proteins developed ELISA, but not virus neutralizing, antibodies in their serum to both whole FeLV and FeLV-gp70.
Birch, D, Johnson, L, Pedersen, NC, Theilen, GH   +3 more
core  

Using Viscum album extracts (ISCADOR) for successful management of neoplasms of the skin in horses and cats in consideration of aspects relevant to human medicine. [PDF]

, 2008
Background: Mistletoe extracts (Viscum album extracts, VAE) such as ISCADOR, have been used successfully in human oncology for many years. In veterinary medicine, there have been reports of successful treatment, but scientific data on efficacy are ...
Biegel, Ulrike, Clottu, Ophélie, Gerber, Vinzenz, Klocke, Peter, Ramos, Mac, Ruess-Melzer, Katja   +5 more
core   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source