Results 131 to 140 of about 1,902,157 (395)

Ivacaftor, not ivacaftor/lumacaftor, associated with lower pulmonary inflammation in preschool cystic fibrosis

, 2022
Shivanthan Shanthikumar, Sarath Ranganathan, Melanie R. Neeland   +2 more
openalex   +1 more source

Are activated B cells involved in the process of myocardial fibrosis after acute myocardial infarction? An in vivo experiment [PDF]

, 2020
Fanrui Mo, Ying Luo, Yuluan Yan, Juan Li, Shayi Lai, Weifeng Wu   +5 more
openalex   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Adipose-derived Mesenchymal Stem Cell Therapy for Reverse Bleomycin-induced Experimental Pulmonary Fibrosis [PDF]

, 2021
Xiansheng Zhao, Jinyan Wu, Ruoyue Yuan, Yue Li, Quyang Yang, Baojin Wu, Xiaowen Zhai, Jiucun Wang, Jérémy Magalon, Winston M. Zhu, Ningwen Zhu   +10 more
openalex   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Physical activity and activity space in patients with pulmonary fibrosis not prescribed supplemental oxygen

BMC Pulmonary Medicine, 2017
Background Patients with pulmonary fibrosis (PF) have impaired quality of life, and research suggests that dyspnea and physical activity are primary drivers. As PF progresses, some patients notice the disease “shrinks their worlds”. The objective of this
Elisabeth Dowling Root, Bridget Graney, Susan Baird, Tara Churney, Kailtin Fier, Majorie Korn, Mark McCormic, David Sprunger, Tomas Vierzba, Frederick S. Wamboldt, Jeffery J. Swigris   +10 more
doaj   +1 more source

High Frequency of the R117H Cystic Fibrosis Mutation in Patients with Congenital Absence of the Vas Deferens [PDF]

, 1993
Radj Gervais, Viviane Dumur, Jean-Marc Rigot, Jean‐Jacques Lafitte, Philippe Roussel, Mireille Claustres, Jacques Demaille   +6 more
openalex   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Ionic‐Electronic Hydrogel‐Liquid Metal Composite Bilayer with Tissue‐Adaptive and Adhesive Properties for Closed‐Loop Neuroprosthetic System

Advanced Functional Materials, EarlyView.
A hydrogel–liquid metal composite peripheral nerve interface (HLB‐PNI) combines electrically durable electrodes and tissue‐adhesive hydrogel for tissue‐adaptive implantation. In nerve‐injured rats, it enables the diagnosis of sensory‐motor connectivity via stimulation and neural signal recording.
Yewon Kim, Kyoungryong Kim, Jaehyon Kim, Heewon Choi, Mikyung Shin, Donghee Son   +5 more
wiley   +1 more source

Televisit with TytoHome™ device in medically complex child in long-term mechanical ventilation: a pilot study

Italian Journal of Pediatrics
Background During the pandemic, the pneumology team at Bambino Gesù Children’s Hospital highlighted that telemedicine was a valuable tool for remotely managing the medical needs of children with medical complexity (CMC).
Alessandro Onofri, Nicola Ullmann, Elisabetta Verrillo, Maria Giovanna Paglietti, Martino Pavone, Renato Cutrera   +5 more
doaj   +1 more source