Results 91 to 100 of about 5,382 (190)

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Sinapine Modulates Glycogen and Lipid Synthesis via IRS1–PI3K–AKT–GSK3β–GS Pathway in Insulin‐Resistant Models

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study combined network pharmacology, molecular docking, and in vitro (HepG2) and in vivo (T2DM mice) experiments to investigate sinapine's effect on insulin resistance. Sinapine was found to modulate the IRS1–PI3K–AKT–GSK3β–GS pathway. In vitro, sinapine improved glucose uptake, enhanced glycogen synthesis, and reduced lipogenesis and ROS. In vivo,
Tiancheng Xing, Yiling Bai, Weijie Wu, Ziqi Zhao, Hanyu Kong, Qianyi Zhang, Shuoqi Li, Yan Liu, Xiaohui Guo, Zengli Wang   +9 more
wiley   +1 more source

A Comparison of Emotionally Stimulated and Conventionally Collected Tears Using Bottom‐Up, Label‐Free Quantitative Proteomic Analysis—A Pilot Study

PROTEOMICS – Clinical Applications, Volume 20, Issue 1, January 2026.
ABSTRACT Proteomic analysis of biofluids is central for identifying disease biomarkers. Tears have become popular targets for biomarker discovery and biosensor development, largely because they can be collected noninvasively and are rich sources of biomarkers for ocular and systemic diseases. Although basal and reflex tears have been well characterized,
Campbell Bruce Mousseau, Alena R. Veigl‐Lunsford, Rhonda L. Pitsch, Sean W. Harshman   +3 more
wiley   +1 more source

Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets. [PDF]

, 2008
[EN]How viral and host factors contribute to the severe pathogenicity of the H5N1 subtype of avian influenza virus infection in humans is poorly understood.
Bermejo Martín, Jesús Francisco, Cameron, Cheryl M, Cameron, Mark J, Chan, Pak-Kei M, Collins, Tassie L, Danesh, Ali, Fang, Yuan, Johnson, Michael G, Kelvin, David J, Medina, Julio C, Mytle, Nutan, Ran, Longsi, Ran, Ran, Rowe, Thomas, Sullivan, Timothy J, Turner, Patricia V, Xu, Luoling   +16 more
core   +2 more sources

Integrated Network Pharmacology, Single‐Cell Transcriptomics Unveil the Mechanistic Role of Morusin in Aortic Dissection

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Aortic dissection is a life‐threatening cardiovascular emergency with limited pharmacological options. This study focuses on elucidating the multi‐target and multi‐pathway mechanisms through which morusin mitigates aortic dissection progression, integrating network pharmacology, single‐cell transcriptomics and experimental validation.
Zhaomeng Wang, Haoran Zhang, Zhanxiong Xie, Yukun Xiang, Yiwen Fu, Zixun Wang, Haiqing Jiao, Nan Lin, Chenguang Niu, Chao Jiang, Lemin Zheng   +10 more
wiley   +1 more source

The Emerging Role of Complement Lectin Pathway in Trypanosomatids: Molecular Bases in Activation, Genetic Deficiencies, Susceptibility to Infection, and Complement System-Based Therapeutics [PDF]

, 2013
The innate immune system is evolutionary and ancient and is the pivotal line of the host defense system to protect against invading pathogens and abnormal self-derived components. Cellular and molecular components are involved in recognition and effector
Iara de Messias-Reason, Ingrid Evans-Osses, Marcel I. Ramirez   +2 more
core   +2 more sources

대동맥판만협착증 환자에서 당뇨에 의한 혈장단백체의 변화 및 심근의 재형성과 예후와의 관련성 연구 [PDF]

, 2022
학위논문(박사) -- 서울대학교대학원 : 의과대학 의학과, 2022. 8. 김용진.Background: It is unclear whether and how diabetes mellitus may aggravate myocardial fibrosis and remodeling in the pressure-overloaded heart. We investigated the impact of diabetes on the prognosis of aortic
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core  

C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules

Frontiers in Immunology, 2018
Complement receptor type 1 (CR1) is a multi modular membrane receptor composed of 30 homologous complement control protein modules (CCP) organized in four different functional regions called long homologous repeats (LHR A, B, C, and D). CR1 is a receptor
Mickaël Jacquet, Gianluca Cioci, Guillaume Fouet, Isabelle Bally, Nicole M. Thielens, Christine Gaboriaud, Véronique Rossi   +6 more
doaj   +1 more source

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

Kidney International Reports, 2018
IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J. Lomax-Browne, Annette G. Hansen, Michelle Willicombe, Charles D. Pusey, H. Terence Cook, Steffen Thiel, Matthew C. Pickering   +9 more
doaj   +1 more source

Ficolin B in Diabetic Kidney Disease in a Mouse Model of Type 1 Diabetes

Mediators of Inflammation, 2015
Background. The innate immune system may have adverse effects in diabetes and cardiovascular disease. The complement system seems to play a key role through erroneous complement activation via hyperglycaemia-induced neoepitopes.
Charlotte Berg Holt, Jakob Appel Østergaard, Esben Axelgaard, Gitte Krogh Nielsen, Yuichi Endo, Steffen Thiel, Troels Krarup Hansen   +6 more
doaj   +1 more source