Results 61 to 70 of about 5,382 (190)

Screening for immune-potentiating antigens from hepatocellular carcinoma patients after radiofrequency ablation by serum proteomic analysis

BMC Cancer, 2018
Background Radiofrequency ablation (RFA) can not only effectively kill hepatocellular carcinoma (HCC) tumour cells but also release tumour antigens that can provoke an immune response.
Shunli Shen, Hong Peng, Ye Wang, Ming Xu, Manxia Lin, Xiaoyan Xie, Baogang Peng, Ming Kuang   +7 more
doaj   +1 more source

Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors

Frontiers in Immunology, 2021
Thousands of leprosy patients not only suffer from physical deformities, but also either have or have had hepatitis B virus (HBV) coinfection. Polymorphisms of the complement system modulate susceptibility to leprosy, but genetic susceptibility to past ...
Angelica Beate Winter Boldt, Angelica Beate Winter Boldt, Camila de Freitas Oliveira-Toré, Gabriela Canalli Kretzschmar, Hellen Weinschutz Mendes, Sérvio Túlio Stinghen, Fabiana Antunes Andrade, Valéria Bumiller-Bini, Letícia Boslooper Gonçalves, Anna Carolina de Moraes Braga, Ewalda von Rosen Seeling Stahlke, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Thirumalaisamy P. Velavan, Steffen Thiel, Iara José Taborda de Messias-Reason   +15 more
doaj   +1 more source

Persistence of Innate Immune Pathways in Late Stage Human Bacterial and Fungal Keratitis: Results from a Comparative Transcriptome Analysis [PDF]

, 2017
Microbial keratitis (MK) is a major cause of blindness worldwide. Despite adequate antimicrobial treatment, tissue damage can ensue. We compared the human corneal transcriptional profile in late stage MK to normal corneal tissue to identify pathways ...
Andersson-Sjoland, Bader, Benjamini, Berger, Bhandari, Burns, Burton, Chai, Du, Dyrlund, Enright, Eriksen, Galarreta, Gopinathan, Gorscak, Guarner, Gurung, Hassell, Hopfer, Huang, Huang, Illumina, Karthikeyan, Karthikeyan, Kernacki, Leal, Levy, Lin, Lin, Matsubara, McClellan, McElvanney, Mia, Mulholland, Nakasaki, Patel, Poole, Saghizadeh, Sanchis-Gimeno, Schaefer, Smyth, Srinivasan, Steuhl, Sun, Theocharidis, Thomas, Tuft, Venkatesan, Whitcher, Wilhelmus, Williams, Wong   +51 more
core   +2 more sources

Multi-Omics Integration-Based Prioritisation of Competing Endogenous RNA Regulation Networks in Small Cell Lung Cancer : Molecular Characteristics and Drug Candidates [PDF]

, 2022
BackgroundThe competing endogenous RNA (ceRNA) network-mediated regulatory mechanisms in small cell lung cancer (SCLC) remain largely unknown. This study aimed to integrate multi-omics profiles, including the transcriptome, regulome, genome and ...
Gao, Jing, Hu, Wei-Dong, Wang, Xiao-Jun, Yu, Qin, Zhang, Min   +4 more
core   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin.

PLoS ONE, 2012
BackgroundThe innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells.
Christian Gytz Ammitzbøll, Troels Rønn Kjær, Rudi Steffensen, Kristian Stengaard-Pedersen, Hans Jørgen Nielsen, Steffen Thiel, Martin Bøgsted, Jens Christian Jensenius   +7 more
doaj   +1 more source

Genomic approaches in the search for molecular biomarkers in chronic kidney disease [PDF]

, 2018
Background Chronic kidney disease (CKD) is recognised as a global public health problem, more prevalent in older persons and associated with multiple co-morbidities.
Anderson, Kerry, Cañadas-Garre, Marisa, Maxwell, Alexander, McGoldrick, Jayne, McKnight, Amy   +4 more
core   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

Complement lectin pathway protein levels reflect disease activity in juvenile idiopathic arthritis: a longitudinal study of the Nordic JIA cohort

Pediatric Rheumatology Online Journal, 2019
Background To determine the serum levels of the lectin pathway proteins early in the disease course and 17 years after disease onset and to correlate the protein levels to markers of disease activity in participants from a population-based Nordic ...
Mia Glerup, Steffen Thiel, Veronika Rypdal, Ellen Dalen Arnstad, Maria Ekelund, Suvi Peltoniemi, Kristiina Aalto, Marite Rygg, Susan Nielsen, Anders Fasth, Lillemor Berntson, Ellen Nordal, Troels Herlin, for the Nordic Study Group of Pediatric Rheumatology (NoSPeR)   +13 more
doaj   +1 more source

Lectin Pathway of Complement Activation Is Associated with Vulnerability of Atherosclerotic Plaques [PDF]

, 2017
Inflammatory mechanisms may be involved in atherosclerotic plaque rupture. By using a novel histology-based method to quantify plaque instability here, we assess whether lectin pathway (LP) of complement activation, a major inflammation arm, could ...
De Blasio, Daiana, De Nigris, Francesca, De Simoni, Maria-Grazia, Ferrante, Angela M R, Fumagalli, Stefano, Garred, Peter, Oggioni, Marco, Perego, Carlo, Snider, Francesco, Zangari, Rosalia   +9 more
core   +2 more sources