Results 161 to 170 of about 5,472 (201)

The Role of Ficolins in Lung Injury. [PDF]

J Innate Immun
Zhao M, Tan X, Wu X.
europepmc   +1 more source

Plasma proteins and mechanisms involved in the evolvement of cardiac function after myocardial infarction. [PDF]

Sci Rep
Petersen TB, Rizopoulos D, Boersma E, Pinet F, Kardys I, Bauters C.   +5 more
europepmc   +1 more source

Membranous nephropathy - an antigen-specific disease: a paradigm shift in the understanding of this disease. [PDF]

Int J Clin Exp Pathol
Rajagopal MD, Stephen N, Manoharan K.
europepmc   +1 more source

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Pre-transplant levels of ficolin-3 are associated with kidney graft survival

Clinical Immunology, 2013
Ficolin-3 is an initiator of the lectin complement pathway. The complement system is a mediator of the pathophysiology of graft rejection in kidney transplantation, but the role of ficolin-3 in this process is unknown. Using a prospective study design, 527 kidney transplanted patients were included. 97 blood donors served as controls. Ficolin-3, C4 and
Estrid Hein, Peter Garred
exaly   +4 more sources

Ficolin-3 Deficiency Is Associated with Disease and an Increased Risk of Systemic Lupus Erythematosus

Journal of Clinical Immunology, 2019
Ficolin-3 deficiency is caused by a mutation (+1637delC) in the FCN3 gene. It is a rare condition and has been associated with both infection and autoimmune disease including systemic lupus erythematosus (SLE). Here we investigated if ficolin-3 deficiency is more frequent in patients than in controls and tried to identify a common phenotype among ...
Anne Troldborg, Rudi Steffensen, Marten Trendelenburg   +2 more
exaly   +9 more sources

Ficolin-3 in rheumatic fever and rheumatic heart disease

Immunology Letters, 2021
Rheumatic fever (RF) and chronic rheumatic heart disease (RHD) are complications of oropharyngeal infection caused by Streptococcus pyogenes. Despite the importance of the complement system against infections and autoimmunity diseases, studies on the role of the lectin pathway in RF and RHD are scarce.
Sandra Jeremias, Catarino, Fabiana Antunes, Andrade, Lorena, Bavia, Luiza, Guilherme, Iara Jose, Messias-Reason   +4 more
openaire   +2 more sources

An electrochemical immunosensor for quantitative detection of ficolin-3

Nanotechnology, 2016
Diabetes mellitus (DM) is one of the most common metabolic disorders in the world, of which more than 90% is type-2 diabetes mellitus (T2DM). There is a rather urgent need for reliable, sensitive and quick detection techniques in clinical application of T2DM. Ficolin-3 is a potential biomarker of T2DM, because serum ficolin-3 levels are associated with
Lili, San, Dongdong, Zeng, Shiping, Song, Xiaolei, Zuo, Huan, Zhang, Chenguang, Wang, Jiarui, Wu, Xianqiang, Mi   +7 more
openaire   +2 more sources

Immunodeficiency associated with FCN3 mutation and Ficolin-3 deficiency

Molecular Immunology, 2009
Ficolin-3, encoded by the FCN3 gene and expressed in the lung and liver, is a recognition molecule in the lectin pathway of the complement system. Heterozygosity for an FCN3 frameshift mutation (rs28357092), leading to a distortion of the C-terminal end of the molecule, occurs in people without disease (allele frequency among whites, 0.01). We describe
Munthe-Fog, Lea, Hummelshøj, Tina, Honoré, Christian, Madsen, Hans O, Permin, Henrik, Garred, Peter   +5 more
openaire   +3 more sources

Low levels of ficolin-3 are associated with diabetic peripheral neuropathy

Acta Diabetologica, 2015
Ficolin-3, a soluble molecule of the innate immune system, has a primary role in the activation of the lectin pathway in the complement system. Considering that inflammatory mechanisms are involved in complement activation and take part in the pathophysiology of diabetic peripheral neuropathy (DPN), we conducted this study to explore the link between ...
Xiaoyan, Zhang, Yanyun, Hu, Jing, Shen, Hui, Zeng, Junxi, Lu, Lianxi, Li, Yuqian, Bao, Fang, Liu, Weiping, Jia   +8 more
openaire   +2 more sources

Levels of clusterin, CD5L, ficolin-3, and gelsolin in ALS patients and controls

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2020
In amyotrophic lateral sclerosis, there is a need for biomarkers to distinguish patients from controls, to follow disease progression and to provide information about the pathogenesis of disease. In a previous mass spectrometry study that searched for potential proteins of interest, we identified clusterin, CD5L, ficolin-3, and gelsolin as molecules ...
Mohanty, Lipsa, Henderson, Robert D., McCombe, Pamela A., Lee, Aven   +3 more
openaire   +4 more sources