Results 41 to 50 of about 3,775 (204)

A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens

Microbial Cell, 2022
Clostridioides difficile (Cdiff) infection (CDI) continues to be the leading threat of nosocomial deaths worldwide and a major burden on health-care systems.
Xinyun Cao, Robert Landick, Elizabeth A. Campbell   +2 more
doaj   +1 more source

Biofilm Formation of Clostridioides difficile, Toxin Production and Alternatives to Conventional Antibiotics in the Treatment of CDI

Microorganisms, 2023
Clostridioides difficile is considered a nosocomial pathogen that flares up in patients exposed to antibiotic treatment. However, four out of ten patients diagnosed with C.
Leon M. T. Dicks
doaj   +1 more source

Fidaxomicin Use in the Pediatric Population with Clostridioides difficile

Clinical Pharmacology: Advances and Applications, 2022
Meredith B Oliver,1 Byron P Vaughn2 1M Health Fairview, Masonic Children’s Hospital, Minneapolis, MN, USA; 2Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN, USACorrespondence: Byron P Vaughn, Department ...
Oliver MB, Vaughn BP
doaj  

High in vitro activity of fidaxomicin against Clostridium difficile isolates from a university teaching hospital in China

Journal of Microbiology, Immunology and Infection, 2018
Background: Clostridium difficile infection (CDI) is a significant cause of morbidity and mortality in both the acute care setting and the wider healthcare system.
Jing-Wei Cheng, Qi-Wen Yang, Meng Xiao, Shu-Ying Yu, Meng-Lan Zhou, Timothy Kudinha, Fanrong Kong, Jian-Wei Liao, Ying-Chun Xu   +8 more
doaj   +1 more source

Impact of the use of local fidaxomicin treatment algorithms for managing Clostridium difficile infection in hospitalized patients in southeastern United States

Annals of Clinical Microbiology and Antimicrobials, 2018
Background Clostridium difficile-associated diarrhea (CDAD) is a major public health threat that results in increased length of stay, hospital readmissions, deaths, and economic burden. CDAD treatment is often guided by severity of disease.
Jonathan C. Cho, Sandy J. Estrada, Jamie J. Kisgen, Angelina Davis, Laura Puzniak   +4 more
doaj   +1 more source

Going Retro, Going Viral: Experiences and Lessons in Drug Discovery from COVID-19

Molecules, 2022
The severity of the COVID-19 pandemic and the pace of its global spread have motivated researchers to opt for repurposing existing drugs against SARS-CoV-2 rather than discover or develop novel ones.
Bing Wang, Dmitri Svetlov, Dylan Bartikofsky, Christiane E. Wobus, Irina Artsimovitch   +4 more
doaj   +1 more source

Reduction in Clostridium difficile environmental contamination by hospitalized patients treated with fidaxomicin. [PDF]

, 2015
Fidaxomicin is sporicidal and may be associated with a reduced time to resolution of diarrhoea when used to treat patients with Clostridium difficile infection (CDI).
Wade, P, Biswas, JS, Otter, JA, Goldenberg, SD, Patel, A., Patel, A, Goldenberg, S.D., Biswas, J.S., Otter, J.A., Wade, P., Newsholme, W., van Kleef, E., Newsholme, W, van Kleef, E   +13 more
core   +1 more source

Controversies in the Prevention and Treatment of Clostridioides difficile Infection in Adults: A Narrative Review

Microorganisms, 2023
Clostridioides difficile remains a problematic pathogen resulting in significant morbidity and mortality, especially for high-risk groups that include immunocompromised patients.
Taryn B. Bainum, Kelly R. Reveles, Ronald G. Hall, Kelli Cornell, Carlos A. Alvarez   +4 more
doaj   +1 more source

Nanjing Consensus II on Washed Microbiota Transplantation: Statements From the CHINAGUT Conference

Microbiota Medicine Research, Volume 1, Issue 2, Page 45-62, June 2026.
ABSTRACT The new method of fecal microbiota transplantation, based on automatic facilities and washing processes, was coined as washed microbiota transplantation (WMT). The first recommendations on WMT were released as Nanjing Consensus report by the fecal microbiota transplantation (FMT)‐standardization Study Group in 2019.
Faming Zhang, Sunny Hei Wong, Gaochen Lu, Zheshun Pi, Ting Zhang, Hon Ho Yu, Nan Bu, Xiong Chen, Bota Cui, Dafa Ding, Hainv Gao, Suyu He, Xingxiang He, Shengjuan Hu, Jia Hu, Yunlian Hu, Xiaomeng Jiang, Jiang Jin, Jingnan Li, Pan Li, Juan Liao, Weiwei Liao, Jiang Liu, Ling Liu, Yaping Liu, Yanyan Liu, Yu Liu, Muhan Lv, Xiangjun Meng, Yongzhan Nie, Qian Ren, Lixuan Sang, Yang Sun, Xiaowen Tang, Liangjing Wang, Wei Wang, Xin Wang, Yanling Wei, Quan Wen, Lihao Wu, Xia Wu, Fang Xiao, Lijing Xiong, Shaoqi Yang, Song Yang, Guoliang Ye, Yue Zeng, Huihong Zhai, Xiaoqian Zhang, Yu Zhang, Kun Zhao, Li Zhou, Li Zhu, Kaichun Wu   +53 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Next Generation Fidaxomicin Antibiotics [PDF]

, 2020
Natural products and natural product derived compounds are popular sources of new drugs and thus also play a pivotal role in the discovery and development of new antibiotics.
Dorst, Andrea
core   +1 more source