Results 231 to 240 of about 9,942 (285)

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex

The Journal of Physiology, EarlyView.
Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg, Pieter Nicolaas de Greef, Huibert D. Mansvelder, Mahesh Miikael Karnani   +3 more
wiley   +1 more source

Panoramic voltage‐sensitive optical mapping of contracting hearts using cooperative multiview motion tracking with 12 cameras

The Journal of Physiology, EarlyView.
Abstact figure legend A panoramic 3D optical mapping system was developed, enabling imaging of action potential waves across the entire strongly deforming ventricular surface of beating isolated hearts. The system comprises 12 high‐speed cameras and a soccerball‐shaped imaging chamber with 48 light‐emitting diodes (LEDs).
Shrey Chowdhary, Jan Lebert, Shai Dickman, Mason Manetta, Charles Gordon, Jan Christoph   +5 more
wiley   +1 more source

Combined emission ratiometry and motion tracking for optical mapping of contracting hearts: Validation with monophasic action potentials

The Journal of Physiology, EarlyView.
Abstract figure legend Motion‐correction pipeline and validation with monophasic action potential (MAP). Left, contractile motion introduces artefacts in dual‐camera optical signals, with dual‐emission imaging used for ratiometry. Middle, motion correction using motion tracking and ratiometry, with displacement vectors overlaid on images and improved ...
Vineesh Kappadan, Zhen Hua, Johanna B. Tonko, Najmah Mohamed, Jan Lebert, Paraskevas Efstathiou, Yasser Abdelghani, Danya Agha‐Jaffar, Anies Sohi, Xianbo Sun, Jean‐Baptiste Guichard, Jan Christoph, Nicholas S. Peters, Fu Siong Ng   +13 more
wiley   +1 more source

Acute viral encephalitis impacts dense‐core amyloid plaque pathology and dysregulates myeloid responses to amyloid plaques

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Recent epidemiological datasets have associated viral encephalitis exposure (i.e., viral‐induced neuroinflammation) with increased risk of Alzheimer's disease (AD) and dementia, highlighting the need to uncover how it may impact AD neuropathology.
Dominic Ibarra Javonillo, Susana Furman, Lucas Le, Kellie Fernandez, Jazmyn Mulford, Vidushi Singla, Roshni Jha, Kate Inman Tsourmas, Nellie E. Kwang, Kim N. Green, Thomas E. Lane   +10 more
wiley   +1 more source

Prediction of dose reductions and impact of reduced starting doses of CDK4/6i on effectiveness in HR‐positive/HER2‐negative metastatic breast cancer: Real‐world data from the OPAL registry

International Journal of Cancer, Volume 159, Issue 1, Page 244-256, 1 July 2026.
What's New? Balancing efficacy and tolerability is challenging in oncology, as standard dosing often prioritizes maximum tolerated doses over other patient needs. Here, the authors developed a predictive index to identify patients with increased probability of dose reduction in metastatic breast cancer and compared the real‐world effectiveness of ...
Patrick Marschner, Kai Ringwald, Marc Thill, Mark‐Oliver Zahn, Anja Welt, Arnd Nusch, Gabriele Kaltenecker, Yolanda Rodemer, Volker Hagen, Caroline Schock, Lisa Kruggel, Anja Kaiser‐Osterhues, Dunja Klein, Nina Haug, Elmar Stickeler, Nadia Harbeck, Achim Wöckel, Norbert Marschner, Thomas Decker, the OPAL Registry Group   +19 more
wiley   +1 more source

Machine Learning‐Driven Capillary Microfluidic Design Automation for Programmable Gradient Generation and Antimicrobial Testing

Small, Volume 22, Issue 37, 2 July 2026.
TCG‐CMDA, a machine learning‐guided capillary microfluidic design automation platform, enables automated design of tree‐shaped concentration gradient generators for programmable mixing of two agents. The pump‐free chip supports synchronized passive flow and programmable gradient formation, providing a practical framework for decentralized point‐of‐care
Mahmood Khalghollah, Azam Zare, Sorosh Abdollahi, Behrouz H. Far, Amir Sanati Nezhad   +4 more
wiley   +1 more source

Seladelpar Improved Itch, Itch‐Related Sleep Disturbance and Measures of Fatigue in Patients With Primary Biliary Cholangitis and Pruritus in the Phase 3 RESPONSE Trial

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 23-35, July 2026.
Seladelpar improved itch, itch‐related sleep disturbance and measures of fatigue in patients with primary biliary cholangitis and pruritus in the Phase 3 RESPONSE trial. ABSTRACT Background Pruritus and fatigue impose a significant burden on patient quality of life in primary biliary cholangitis (PBC).
Cynthia Levy, David E. J. Jones, Marlyn J. Mayo, Christopher L. Bowlus, Kris V. Kowdley, Gideon M. Hirschfield, Jie Liu, Caroline Burk, Susheela Carroll, Daria B. Crittenden, Andreas E. Kremer   +10 more
wiley   +1 more source

Affinity Proteomics‐Based Non‐Invasive Detection of Clinically Significant Liver Disease

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 1, Page 74-88, July 2026.
Using UK Biobank proteomic data, we identified a five‐protein score reflecting hepatic stellate cell activation and hepatocellular injury that predicts major adverse liver outcomes and clinically significant fibrosis, with consistent performance validated in two independent cohorts (patients with HIV and alpha1‐antitrypsin deficiency).
Sriram Balasubramani, Katharina Remih, Anna Sophie Karl, Julia Alexandra Borchert, Christina Schrader, Malin Fromme, Can Kayatekin, Bailin Zhang, Mikhail Levit, Pavithra Krishnaswami, Louise E. van Eekeren, Leo A. B. Joosten, Twan Otten, Petra Tomanová, Pavel Strnad   +14 more
wiley   +1 more source

Low‐Carbon Transition and Active Management: Evidence From Emerging Market Funds

Business Ethics, the Environment &Responsibility, Volume 35, Issue 3, Page 1886-1906, July 2026.
ABSTRACT Previous literature finds mixed evidence on the performance of emerging mutual funds and how investors are becoming more aware of investing in companies involved in low‐carbon emission activities. Given the opportunities that emerging markets and sustainable investing offer to active management, this study aims to fill a gap in the literature ...
Juan Carlos Matallín‐Sáez, Amparo Soler‐Domínguez, Diego Víctor de Mingo‐López   +2 more
wiley   +1 more source

Who Is Smuggler? Contradictory Positions and Unsettled Roles in Smuggling Assemblage on the Balkan Route

Global Networks, Volume 26, Issue 3, July 2026.
ABSTRACT This article reconceptualizes migrant smuggling along the Balkan Route through the lens of the smuggling assemblage, which captures the fluid, relational and context‐dependent nature of clandestine mobility. Based on multi‐sited ethnographic fieldwork between 2020 and 2023 across six countries, including 85 semi‐structured interviews and ...
Muhammed Yasir Bodur, Mustafa Ammar Kılıç   +1 more
wiley   +1 more source