Results 61 to 70 of about 44,266 (250)

Purification of Au/Au Core/Satellite Supraparticles by Asymmetric Flow Field Flow Fractionation for SERS Nanotag-based Applications [PDF]

Over the last decades, nanoparticles have been increasingly used in biomedical applications, such as immunolabelling, requiring high control over size and shape.
Annika, Kleinschmidt, Elzbieta , Stepula, Louisa, Waasmann, Carolin, Sanders, Sebastian, Schlücker, Bernd, Walkenfort   +5 more
core   +1 more source

Application of Af4-Multidetection to Liraglutide in Its Formulation: Preserving and Representing Native Aggregation

Molecules, 2022
Aggregation is among the most critical parameters affecting the pharmacological and safety profile of peptide Active Pharmaceutical Ingredients (APIs).
Valentina Marassi, Marco Macis, Stefano Giordani, Lucia Ferrazzano, Alessandra Tolomelli, Barbara Roda, Andrea Zattoni, Antonio Ricci, Pierluigi Reschiglian, Walter Cabri   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Silicon isotope fractionation during silica precipitation from hot-spring waters: Evidence from the Geysir geothermal field, Iceland [PDF]

, 2015
This study aims to explore the extent and controls of silicon isotope fractionation in hot spring systems of the Geysir geothermal area (Iceland), a setting where sinter deposits are actively formed.
Keller, Nicole S., van Bergen, M.J., Gudbrandsson, S., Keller, N.S., van Bergen, Manfred J., Vroon, Pieter Z., Petrology, Geilert, Sonja, Stefánsson, Andri, NWO-ALW Open: Exploring the Earth's earliest oceans with silicon: magnitudes of isotopic fractionation, Vroon, P.Z.; id_orcid, Gudbrandsson, Snorri, Geilert, S., Vroon, P.Z., Stefánsson, A.   +14 more
core   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

FIELD-FLOW FRACTIONATION FOR POISEUILLE FLOW THROUGH A CYLINDRICAL TUBE [PDF]

, 1991
We calculate the longitudinal dispersion coefficient K for field-flow fractionation in a cylindrical tube by using a variational ...
VAN DEN BROECK, Christian, Maes, Dominique   +1 more
core   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Field-Flow Fractionation Fundamentals [PDF]

, 2016
Theory and fundamentals of the Field-Flow Fractionation method are presented in this chapter.
Janča, Josef
core  

Magnetic field programming in quadrupole magnetic field-flow fractionation [PDF]

, 2010
Magnetic field-flow fractionation (MgFFF) is a technique for the separation and characterization of magnetic nanoparticles. It is explained that the analysis of polydisperse samples requires a programmed decay of field and field gradient during sample ...
Moore, Lee R., Carpino, Francesca, Maciej Zborowski, Francesca Carpino, Stephen Williams, P., Lee R. Moore, P. Stephen Williams, Zborowski, Maciej   +7 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source