Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
EXPLICITLY ACCOUNTING FOR UNCERTAINTY IN CROWDSOURCED DATA FOR SPECIES DISTRIBUTION MODELLING [PDF]
Species distribution models represent an important approach to map the spread of plant and animal species over space (and time). As all the statistical modelling techniques related to data from the field, they are prone to uncertainty.
D. Rocchini +8 more
doaj +1 more source
SUNRISE/IMaX observations of convectively driven vortex flows in the Sun
We characterize the observational properties of the convectively driven vortex flows recently discovered on the quiet Sun, using magnetograms, Dopplergrams and images obtained with the 1-m balloon-borne Sunrise telescope.
Almeida, J. Sanchez +12 more
core +1 more source
Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy. [PDF]
Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits.
Barkovich, A James +9 more
core +2 more sources
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
The Structural Diversity of ABS3 Compounds with d0 Electronic Configuration for the B-cation
We use first-principles density functional theory (DFT) within the local density approx- imation (LDA) to ascertain the ground state structure of real and theoretical compounds with the formula ABS3 (A = K, Rb, Cs, Ca, Sr, Ba, Tl, Sn, Pb, and Bi; and B =
Bennett, Joseph W. +4 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
KMapper: A Field Geological Survey System
The computing power of smart mobile devices has evolved as much as the power of desktop personal computers (PCs). Accordingly, a field geological survey system capable of utilizing the performance of smart devices is needed.
Young-Kwang Yeon
doaj +1 more source
Magnetic field distribution and characteristic fields of the vortex lattice for a clean superconducting niobium sample in an external field applied along a three-fold axis [PDF]
The field distribution in the vortex lattice of a pure niobium single crystal with an external field applied along a three-fold axis has been investigated by the transverse-field muon-spin-rotation (TF-$\mu$SR) technique over a wide range of temperatures
Amato, A. +11 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source

