Results 61 to 70 of about 9,119,744 (254)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Road Traffic Accident Data Standardization System Based on Field Map
IEEE AccessIn the field of accident identification, the Crashview system, which is the only software that meets the national standards for simulating and reproducing road traffic accidents in China, has always been favored by accident identification personnel ...
Wangfang Yuan, Hanjie Lu, Jiatao Zhang
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Application status quo of concept map in nursing field
Huli yanjiu, 2018 This article reviewed the theoretical basis,components,development process,and application status quo of the concept map in the nursing field,focusing on the first evaluation of the concept map and the relationship between the concept map and other ...
雷梦杰 +4 more
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Frontiers in Public HealthObjectiveThe technology employed in magnetic resonance imaging (MRI) systems has evolved continuously, resulting in MRI scanners with stronger static magnetic fields (SMF) B0, faster and stronger gradient magnetic fields, and more powerful radiofrequency
Francesco Girardello +5 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Southeast Asia 1:250,000 [cartographic material] /
, 1954 Various eds. "Constructed and molded in ... from ... 1:250,000, Series 1501 ..."; Also shows aeronautical information.; Includes index to adjoining sheets and glossary.; Raised relief model map series of Southeast Asia (Thailand and Indochina) showing ...
United States. Army Map Service.
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source