Results 41 to 50 of about 151,004 (259)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Characterisation of Serbian durum wheat genotypes based on UPOV-defined characteristics [PDF]
Ratarstvo i Povrtarstvo, 2019 Estimation of the level of durum wheat germplasm genetic diversity is important for its classification and efficient use in breeding programmes. The aim of this study was to assess genetic diversity of durum wheat genotypes developed at the Institute of ...
Takač Verica +6 more
doaj
Determination of the optimal doses of gamma irradiation for induced mutation in wheat and barley [PDF]
Ratarstvo i PovrtarstvoOne of the major challenges that plant breeders face in the 21st century is food safety for growing human population coupled with extreme climate changes.
Glogovac Svetlana +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Sunflower seed germination and storability response to chemical desiccation [PDF]
Selekcija i Semenarstvo, 2020 The objective was to assess the effect of chemical desiccation on seed germination and storability in three sunflower female inbred lines and to point at possible indicators for optimal performance time.
Čanak Petar +6 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Antioxidant enzymes activities in Vicia seedlings during drought stress [PDF]
Ratarstvo i Povrtarstvo, 2018 Drought greatly affects normal plant growth, endangering physiological and biochemical processes in plants. Under the influence of unfavorable environmental conditions, antioxidant protection systems in plant cell can be activated regardless of the stage
Jovičić Dušica +6 more
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Soil Science, 1950 "References" at end of each chapter. ; Mode of access: Internet.
Leonard, Warren H., 1900- +1 more
openaire +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source