Results 41 to 50 of about 160,658 (219)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Characterisation of Serbian durum wheat genotypes based on UPOV-defined characteristics [PDF]

Ratarstvo i Povrtarstvo, 2019
Estimation of the level of durum wheat germplasm genetic diversity is important for its classification and efficient use in breeding programmes. The aim of this study was to assess genetic diversity of durum wheat genotypes developed at the Institute of ...
Takač Verica, Mikić Sanja, Mirosavljević Milan, Momčilović Vojislava, Trkulja Dragana, Kondić-Špika Ankica, Brbaklić Ljiljana   +6 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Antioxidant enzymes activities in Vicia seedlings during drought stress [PDF]

Ratarstvo i Povrtarstvo, 2018
Drought greatly affects normal plant growth, endangering physiological and biochemical processes in plants. Under the influence of unfavorable environmental conditions, antioxidant protection systems in plant cell can be activated regardless of the stage
Jovičić Dušica, Nikolić Zorica, Mikić Aleksandar, Milošević Branko, Milošević Dragana, Ignjatov Maja, Marinković Dragana   +6 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Biplot analysis of seed priming effects on maize seedling growth traits [PDF]

Ratarstvo i Povrtarstvo, 2018
The objectives of this study were to determine the effects of different priming treatments and genotypes on maize germination and early seedling growth traits, as well as to examine the associations among these traits.
Čanak Petar, Mirosavljević Milan, Zorić Miroslav, Ćirić Mihajlo, Vujošević Bojana, Mitrović Bojan, Stanisavljević Dušan   +6 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Sunflower seed germination and storability response to chemical desiccation [PDF]

Selekcija i Semenarstvo, 2020
The objective was to assess the effect of chemical desiccation on seed germination and storability in three sunflower female inbred lines and to point at possible indicators for optimal performance time.
Čanak Petar, Jocković Milan, Vujošević Bojana, Babić Milosav, Mitrović Bojan, Stanisavljević Dušan, Miklič Vladimir   +6 more
doaj  

STUDIES ON THE VARIABILITY AND THE CORRELATION BETWEEN YIELD AND ITS COMPONENTS IN SESAME (Sesamum indicum L.) [PDF]

Journal of Plant Production, 2000
Evaluation of 17 sesame genotypes were carried out at two locations (Mallawi and Shandaweel Research Stations, ARC) in two successive seasons (1998 and 1999). Combined analysis was done for the four experiments for some characters.
M. El-Baz, W. Sorour, M. Abou-Ghazala,
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source