Results 31 to 40 of about 916,501 (300)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Characterisation of Serbian durum wheat genotypes based on UPOV-defined characteristics [PDF]

open access: yesRatarstvo i Povrtarstvo, 2019
Estimation of the level of durum wheat germplasm genetic diversity is important for its classification and efficient use in breeding programmes. The aim of this study was to assess genetic diversity of durum wheat genotypes developed at the Institute of ...
Takač Verica   +6 more
doaj  

Chemical Weed Control in Field Crops [PDF]

open access: yes, 1953
PDF pages ...
Willard, C. J.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Antioxidant enzymes activities in Vicia seedlings during drought stress [PDF]

open access: yesRatarstvo i Povrtarstvo, 2018
Drought greatly affects normal plant growth, endangering physiological and biochemical processes in plants. Under the influence of unfavorable environmental conditions, antioxidant protection systems in plant cell can be activated regardless of the stage
Jovičić Dušica   +6 more
doaj  

Phenotypic and molecular evaluation of genetic diversity in ns safflower (Carthamus tinctorius L.) collection [PDF]

open access: yesZbornik Matice Srpske za Prirodne Nauke, 2016
Safflower (Carthamus tinctorius L.) belongs to the Asteraceae (Compositae) family. It is primarily grown for seeds used for bird feed or as edible oil. Stamens are used in traditional medicine and nutrition.
Marjanović-Jeromela Ana M.   +7 more
doaj   +1 more source

The effect of within-crop habitat manipulations on the conservation biological control of aphids in field-grown lettuce [PDF]

open access: yes, 2011
Within-crop habitat manipulations have the potential to increase the biological control of pests in horticultural field crops. Wildflower strips have been shown to increase the abundance of natural enemies, but there is little evidence to date of an ...
Kravar-Garde, L. (Lidija)   +4 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Comparison of methods for germination testing of Cannabis sativa seed [PDF]

open access: yesRatarstvo i Povrtarstvo, 2019
The most critical aspect of plant survival and reproduction is seed germination. Considering the specificity of the Cannabis sativa production, obtaining high-quality hemp seed is not an easy task.
Jovičić Dušica   +6 more
doaj  

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