Results 91 to 100 of about 18,593,124 (392)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Elevational distribution patterns and drivers factors of fungal community diversity at different soil depths in the Abies georgei var. smithii forests on Sygera Mountains, southeastern Tibet, China

Frontiers in Microbiology
IntroductionSoil fungal communities play a crucial role in maintaining the ecological functions of alpine forest soil ecosystems. However, it is currently unclear how the distribution patterns of fungal communities in different soil layers of alpine ...
Bo Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Sijie Zhu, Sijie Zhu, Sijie Zhu, Sijie Zhu, Jiangrong Li, Jiangrong Li, Jiangrong Li, Jiangrong Li, Jiangrong Li, Fangwei Fu, Fangwei Fu, Fangwei Fu, Fangwei Fu, Liangna Guo, Liangna Guo, Liangna Guo, Liangna Guo, Jieting Li, Jieting Li, Jieting Li, Jieting Li, Yibo Zhang, Yibo Zhang, Yibo Zhang, Yibo Zhang, Yuzhuo Liu, Yuzhuo Liu, Yuzhuo Liu, Yuzhuo Liu, Ganggang Chen, Ganggang Chen, Ganggang Chen, Ganggang Chen, Gengxin Zhang   +37 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Free Riding in the Lab and in the Field [PDF]

We run a public good experiment in the field and in the lab with (partly) the same subjects. The field experiment is a true natural field experiment as subjects do not know that they are exposed to an experimental variation.
Englmaier, Florian, Gebhardt, Georg
core  

Zero-field and Larmor spinor precessions in a neutron polarimeter experiment

, 2008
We present a neutron polarimetric experiment where two kinds of spinor precessions are observed: one is induced by different total energy of neutrons (zero-field precession) and the other is induced by a stationary guide field (Larmor precession).
Alefeld, Badurek, G. Badurek, Golub, Greenberger, Grigoriev, Gähler, Gähler, Haroche, Hasegawa, Hasegawa, Hasegawa, Hasegawa, Hasegawa, J. Klepp, Klepp, Kraan, Nielsen, Rauch, S. Sponar, Summhammer, Wagh, Y. Hasegawa, Yamazaki   +23 more
core   +1 more source

Investing with Brain or Heart? A Field Experiment on Responsible Investment

Management Sciences, 2016
Socially responsible investment is increasingly prevalent in financial markets and is characterized by the integration of financial and nonfinancial objectives.
Trond Døskeland, L. J. T. Pedersen
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Efficient droplet activation of ambient black carbon particles in a suburban environment [PDF]

Atmospheric Chemistry and Physics
The cloud condensation nuclei (CCN) activity of black carbon (BC) particles importantly determines their impacts on cloud microphysics and atmospheric lifetime.
P. Tian, D. Liu, K. Hu, K. Hu, Y. Wu, Y. Wu, M. Huang, M. Huang, H. He, H. He, J. Sheng, J. Sheng, C. Yu, D. Hu, D. Ding, D. Ding   +15 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

From the lab to the field: envelopes, dictators and manners [PDF]

Results are reported of the first natural field experiment on the dictator game, where subjects are unaware that they participate in an experiment. In contrast to predictions of the standard economic model, dictators show a large degree of pro-social ...
Stoop, Jan
core   +1 more source