Results 41 to 50 of about 68,641 (256)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Fpga As A Part Of Ms Windows Control Environment
Computer Science, 2007 The attention is focused on the Windows operating system (OS) used as a control and measurementenvironment. Windows OS due to extensions becomes a real-time OS (RTOS).Benefits and drawbacks of typical software extensions are compared.
Krzysztof Kołek, Andrzej Turnau
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
The average size of 3-torsion in class groups of 2-extensions
Forum of Mathematics, PiWe determine the average size of the $3$ -torsion in class groups of G-extensions of a number field when G is any transitive $2$ -group containing a transposition, for example $D_4$ .
Robert Lemke Oliver +2 more
doaj +1 more source
Comparison of non-convex cost functionals for the consideration of phase differences in phaseless near-field far-field transformations of measured antenna fields [PDF]
Advances in Radio Science, 2017 This work introduces two methods which extend the non-convex minimization problem arising in phaseless (NF) far-field (FF) transformations. With the new extensions, knowledge about phase differences between measurement points can be incorporated into ...
J. Knapp +3 more
doaj +1 more source
Fields with few extensions [PDF]
Proceedings of the American Mathematical Society, 1971 We show that a valued field Λ \Lambda with only a finite number of nonisomorphic valued extensions is equal to the complex field C \mathbfit {C} or is real closed with C = Λ ( √ ( − 1 ) ) C = \Lambda (\surd ( - 1)) .
Knopfmacher, J., Sinclair, A. M.
openaire +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source