Results 71 to 80 of about 6,505,060 (289)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

High-resolution multi-modal imaging of sub-cellular structures with low numerical aperture objective

JPhys Photonics
Imaging of subcellular structures, which underpins many of the advances in biological and medical sciences, requires microscopes with high numerical aperture (N.A.) objectives which are costly, complex, requires oil immersion and have very limited field ...
Somaiyeh Khoubafarin, Peuli Nath, Saloni Malla, Durgesh Desai, William D Gorgas, Amit K Tiwari, Aniruddha Ray   +6 more
doaj   +1 more source

On the Weakening of Chromospheric Magnetic Field in Active Regions

, 2008
Simultaneous measurement of line-of-sight (LOS) magnetic and velocity fields at the photosphere and chromosphere are presented. Fe I line at $\lambda6569$ and $H_{\alpha}$ at $\lambda6563$ are used respectively for deriving the physical parameters at ...
Casini R., Hanaoka Y., K. E. Rangarajan, K. Nagaraju, K. Sankarasubramanian, Nagaraju K., Rees D. E.   +6 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

System for forming a quadrified image comprising angularly related fields of view of a three dimensional object [PDF]

, 1980
A system for generating, within a single frame of photographic film, a quadrified image including images of angularly (including orthogonally) related fields of view of a near field three dimensional object is described.
Chamberlain, F. R.
core   +1 more source

KIC 9406652: An Unusual Cataclysmic Variable in the Kepler Field of View

, 2013
KIC 9406652 is a remarkable variable star in the Kepler field of view that shows both very rapid oscillations and long term outbursts in its light curve.
Boyajian, Tabetha S., Gies, Douglas R., Guo, Zhao, Hoekstra, Abe J., Howell, Steve B., Jek, Kian J., LaCourse, Daryll, Still, Martin D., Winarski, Troy   +8 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source