Results 61 to 70 of about 1,208,887 (262)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Toroidal Magnetic Flux Budget in Mean-field Dynamo Model of Solar Cycles 23 and 24

The Astrophysical Journal
We study the toroidal magnetic flux budget of the axisymmetric part of a data-driven 3D mean-field dynamo model of Solar Cycles 23 and 24. The model simulates the global solar dynamo that includes the effects of the formation and evolution of bipolar ...
Valery V. Pipin, Alexander G. Kosovichev
doaj   +1 more source

Optimized Multiple Unmanned Surface Vehicle Strategies for Target Tracking with Field of View Constraints

Journal of Marine Science and Engineering
Unmanned surface vehicles (USVs) have garnered significant interest due to their potential in various maritime applications, particularly target tracking.
Kai Xue, Zeyu Xu, Ping Wang, Qiuhong Li, Zhiqin Huang, Decheng Kong   +5 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Kiladze Caldera: A Possible Cryovolcano on Pluto

The Planetary Science Journal
In contrast with regional primarily methane composition, Kiladze and its surroundings exhibit a water-ice spectral signature that carries an ammoniated compound, similar to two other cryovolcanic sites on Pluto.
A. Emran, D. P. Cruikshank, C. J. Ahrens, J. M. Moore, O. L. White   +4 more
doaj   +1 more source

Influence of Field of View and Bowtie Filtration on Cone Beam Computed Tomography Image Quality and Scatter-to-Primary Ratio

Journal of Medical Physics
Purpose/Aim: The image quality (IQ) of cone-beam computed tomography (CBCT) is often reduced due to X-ray scatter, causing issues such as shading, skin-line artifacts, decreased contrast-to-noise ratio, and inaccurate computed tomography (CT) numbers ...
Noor Mail, Batoor Khan, Khalid M. Alshamrani   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Estimation of horizontal spatial specifications for ideal head-mounted displays in practical conditions

Frontiers in Virtual Reality
This study presents the horizontal spatial specifications required for developing ideal head-mounted displays (HMDs) that provide visual experiences indistinguishable from those obtained without wearing HMDs.
Yamato Miyashita, Masamitsu Harasawa, Kazuhiro Hara, Yasuhito Sawahata, Kazuteru Komine   +4 more
doaj   +1 more source