Results 91 to 100 of about 845,144 (302)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
T T ¯ $$ T\overline{T} $$ deformations in curved space from 4D Chern-Simons theory
Journal of High Energy Physics, 2022 In this paper, we shed new light onto T T ¯ $$ T\overline{T} $$ -deformations by engineering them on 2D surface defects, supporting chiral and antichiral CFT’s, in a 4D Chern-Simons bulk. This approach is motivated by various connections between T T ¯ $$
Victor Py
doaj +1 more source
Nonunitary Lagrangians and Unitary Non-Lagrangian Conformal Field Theories. [PDF]
Physical Review Letters, 2017 In various dimensions, we can sometimes compute observables of interacting conformal field theories (CFTs) that are connected to free theories via the renormalization group (RG) flow by computing protected quantities in the free theories.
M. Buican, Z. Laczko
semanticscholar +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Spinors fields in co-dimension one braneworlds
Journal of High Energy Physics, 2018 In this work we analyze the zero mode localization and resonances of 1/2−spin fermions in co-dimension one Randall-Sundrum braneworld scenarios. We consider delta-like, domain walls and deformed domain walls membranes.
W.M. Mendes, G. Alencar, R.R. Landim
doaj +1 more source
Higher-dimension operators in higher-dimensional field theories
, 2005 Universität Hamburg, Diss., 2005; 128 pp., (2005).
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Entanglement entropy, relative entropy and duality
Journal of High Energy Physics, 2019 A definition for the entanglement entropy in both Abelian and non-Abelian gauge theories has been given in the literature, based on an extended Hilbert space construction.
Upamanyu Moitra +2 more
doaj +1 more source
Eisenhart lift for field theories [PDF]
Physical Review D, 2018 We present the Eisenhart-lift formalism in which the dynamics of a system that evolves under the influence of a conservative force is equivalent to that of a free system embedded in a curved manifold with one additional generalised coordinate.
Kieran Finn, S. Karamitsos, A. Pilaftsis
semanticscholar +1 more source