Results 111 to 120 of about 845,144 (302)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A conformal dispersion relation: correlations from absorption

Journal of High Energy Physics, 2020
We introduce the analog of Kramers-Kronig dispersion relations for correlators of four scalar operators in an arbitrary conformal field theory. The correlator is expressed as an integral over its “absorptive part”, defined as a double discontinuity ...
Dean Carmi, Simon Caron-Huot
doaj   +1 more source

The Exact Renormalization Group and Higher-spin Holography

, 2014
In this paper, we revisit scalar field theories in $d$ space-time dimensions possessing $U(N)$ global symmetry. Following our recent work arXiv:1402.1430v2, we consider the generating function of correlation functions of all $U(N)$-invariant, single ...
Leigh, Robert G., Parrikar, Onkar, Weiss, Alexander B.   +2 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Some exact solutions for maximally symmetric topological defects in Anti de Sitter space

Journal of High Energy Physics, 2018
We obtain exact analytical solutions for a class of SO(l) Higgs field theories in a non-dynamic background n-dimensional anti de Sitter space. These finite transverse energy solutions are maximally symmetric p-dimensional topological defects where n = (p
Orlando Alvarez, Matthew Haddad
doaj   +1 more source

Absence of higher derivatives in the renormalization of propagators in quantum field theories with infinitely many couplings [PDF]

, 2002
I study some aspects of the renormalization of quantum field theories with infinitely many couplings in arbitrary space-time dimensions. I prove that when the space-time manifold admits a metric of constant curvature the propagator is not affected by ...
D. Anselmi
semanticscholar   +1 more source

A note on spherically symmetric naked singularities in general dimension

, 2004
We discuss generalizations of the recent theorem by Dafermos (hep-th/0403033) forbidding a certain class of naked singularities in the spherical collapse of a scalar field. Employing techniques similar to the ones Dafermos used, we consider extending the
Dafermos M, Gutperle M, Hawking S W, Hertog T Horowitz G T, Hubeny V E Liu X Rangamani M Shenker S, Peter Langfelder, Robert B Mann   +6 more
core   +3 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source