Results 71 to 80 of about 115,239,083 (281)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Integrable quantum field theories, in the bulk and with a boundary [PDF]

, 2000
In this thesis, we consider the massive field theories in 1+1 dimensions known as affine Toda quantum field theories. These have the special property that they possess an infinite number of conserved quantities, a feature which greatly simplifies their ...
Mattsson, P.A., Mattsson, Peter Aake
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A Rényi quantum null energy condition: proof for free field theories

Journal of High Energy Physics, 2021
The Quantum Null Energy Condition (QNEC) is a lower bound on the stress-energy tensor in quantum field theory that has been proved quite generally.
Mudassir Moosa, Pratik Rath, Vincent Paul Su   +2 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Constraints on chiral operators in N=2 SCFTs [PDF]

, 2014
: We study certain higher-spin chiral operators in (formula presented)(formula presented) superconformal field theories (SCFTs). In Lagrangian theories, or in theories related to Lagrangian theories by generalized Argyres-Seiberg-Gaiotto duality (“type A”
Matthew Buican, Papageorgakis, C, Constantinos Papageorgakis, Takahiro Nishinaka, Nishinaka, T, Buican, M   +5 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A conformal dispersion relation: correlations from absorption

Journal of High Energy Physics, 2020
We introduce the analog of Kramers-Kronig dispersion relations for correlators of four scalar operators in an arbitrary conformal field theory. The correlator is expressed as an integral over its “absorptive part”, defined as a double discontinuity ...
Dean Carmi, Simon Caron-Huot
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Some exact solutions for maximally symmetric topological defects in Anti de Sitter space

Journal of High Energy Physics, 2018
We obtain exact analytical solutions for a class of SO(l) Higgs field theories in a non-dynamic background n-dimensional anti de Sitter space. These finite transverse energy solutions are maximally symmetric p-dimensional topological defects where n = (p
Orlando Alvarez, Matthew Haddad
doaj   +1 more source