Results 51 to 60 of about 45,528 (295)

Higher dimensional theories in physics, following the Kaluza model of unification [PDF]

, 1989
This thesis traces the origins and evolution of higher dimensional models in physics, with particular reference to the five-dimensional Kaluza-Klein unification.
Middleton, Eric William
core  

BPS Wilson loops on S-2 at higher loops [PDF]

, 2008
archiveprefix: arXiv primaryclass: hep-th reportnumber: HU-EP-08-13 slaccitation: %%CITATION = ARXIV:0804.4098;%%archiveprefix: arXiv primaryclass: hep-th reportnumber: HU-EP-08-13 slaccitation: %%CITATION = ARXIV:0804.4098;%%archiveprefix: arXiv ...
Young, D
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Spinors fields in co-dimension one braneworlds

Journal of High Energy Physics, 2018
In this work we analyze the zero mode localization and resonances of 1/2−spin fermions in co-dimension one Randall-Sundrum braneworld scenarios. We consider delta-like, domain walls and deformed domain walls membranes.
W.M. Mendes, G. Alencar, R.R. Landim
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

T T ¯ $$ T\overline{T} $$ deformations in curved space from 4D Chern-Simons theory

Journal of High Energy Physics, 2022
In this paper, we shed new light onto T T ¯ $$ T\overline{T} $$ -deformations by engineering them on 2D surface defects, supporting chiral and antichiral CFT’s, in a 4D Chern-Simons bulk. This approach is motivated by various connections between T T ¯ $$
Victor Py
doaj   +1 more source

Higher-dimension operators in higher-dimensional field theories

, 2005
Universität Hamburg, Diss., 2005; 128 pp., (2005).
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Localization of U(1) gauge vector field on flat branes with five-dimension (asymptotic) AdS5 spacetime

Journal of High Energy Physics, 2018
In order to localize U(1) gauge vector field on Randall-Sundrum-like braneworld model with infinite extra dimension, we propose a new kind of non-minimal coupling between the U(1) gauge field and the gravity.
Zhen-Hua Zhao, Qun-Ying Xie
doaj   +1 more source