Results 51 to 60 of about 46,456 (217)

Rate of cluster decomposition via Fermat-Steiner point

Journal of High Energy Physics, 2019
In quantum field theory with a mass gap correlation function between two spatially separated operators decays exponentially with the distance. This fundamental result immediately implies an exponential suppression of all higher point correlation ...
Alexander Avdoshkin, Lev Astrakhantsev, Anatoly Dymarsky, Michael Smolkin   +3 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A note on non-Lorentzian duality symmetries

Journal of High Energy Physics
We work out non-Lorentzian dual actions for electromagnetism and linearised gravity, both in the Carrollian and Galilean cases. This is done in the same way as for Lorentzian theories, by first constructing a parent action that reduces to a pair of dual ...
Josh A. O’Connor, Simon Pekar
doaj   +1 more source

Some exact solutions for maximally symmetric topological defects in Anti de Sitter space

Journal of High Energy Physics, 2018
We obtain exact analytical solutions for a class of SO(l) Higgs field theories in a non-dynamic background n-dimensional anti de Sitter space. These finite transverse energy solutions are maximally symmetric p-dimensional topological defects where n = (p
Orlando Alvarez, Matthew Haddad
doaj   +1 more source

Endpoint contributions to excited-state modular Hamiltonians

Journal of High Energy Physics, 2020
We compute modular Hamiltonians for excited states obtained by perturbing the vacuum with a unitary operator. We use operator methods and work to first order in the strength of the perturbation.
Daniel Kabat, Gilad Lifschytz, Phuc Nguyen, Debajyoti Sarkar   +3 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

From regular to irregular: a unified origin for Argyres-Douglas theories

Journal of High Energy Physics
We propose that Argyres-Douglas theories of type D p (SU(N)) and (A p−1 , A N−1) — both realizable as Type A class $$\mathcal{S}$$ theories with irregular punctures — can be obtained via a sequence of mass deformations from a common ancestor: a class ...
Simone Giacomelli, William Harding, Noppadol Mekareeya, Alessandro Mininno   +3 more
doaj   +1 more source