Results 41 to 50 of about 45,528 (295)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nonperturbative bounds on scattering of massive scalar particles in d ≥ 2

Journal of High Energy Physics, 2022
We study two-to-two scattering amplitudes of a scalar particle of mass m. For simplicity, we assume the presence of ℤ2 symmetry and that the particle is ℤ2 odd.
Hongbin Chen, A. Liam Fitzpatrick, Denis Karateev   +2 more
doaj   +1 more source

Geometry of black holes and braneworlds in higher dimensions [PDF]

, 2004
This tliesis first discusses braneworld models, we explain how the bulk geometry in codimension 2 scenarios restricts braneworld fields in a way inconsistent with observation.
Paul B. Bostock, Bostock, Paul B, Bostock, Paul B.   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

E 8 instantons on type-A ALE spaces and supersymmetric field theories

Journal of High Energy Physics, 2017
We consider the 6d superconformal field theory realized on M5-branes probing the E 8 end-of-the-world brane on the deformed and resolved ℂ 2/ℤ k singularity.
Noppadol Mekareeya, Kantaro Ohmori, Yuji Tachikawa, Gabi Zafrir   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Discrete gauging in six dimensions

Journal of High Energy Physics, 2018
When n M5 branes coincide on an A type singularity, ℂ2 /ℤ k , there is a multitude of tensionless strings which arise in the spectrum. The low energy theory when all M5 branes are separated at the singularity is given by a linear quiver with parameters n
Amihay Hanany, Gabi Zafrir
doaj   +1 more source

Affine toda field theories on a half-line [PDF]

, 1999
This thesis is primarily concerned with the reflection factors of affine Toda field theories on the half-line x ≤ 0. First, we consider the classical background configurations of low rank a,(^(1)) affine Toda theories with a boundary, constructed by the ...
Perkins, Michael Gordon, Perkins, M.G.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Field redefinitions can be nonlocal

Journal of High Energy Physics
We revisit the lore establishing the allowed space of field redefinitions and show that there are essentially no restrictions. Our conclusions hold to all orders in perturbation theory and for any dispersion relation. Field redefinitions can be nonlocal,
Timothy Cohen, Matthew Forslund, Andreas Helset   +2 more
doaj   +1 more source