Results 1 to 10 of about 17,589 (258)

On Including Pain as an Integral Part of the Fight-or-Flight Response [PDF]

Journal of Pain Research
Robert B Raffa,1,2 Wolfgang Fink,3 Anuj D Tripathi3 1Temple University (Emeritus), Philadelphia, PA, USA; 2University of Arizona (Adjunct), Tucson, AZ, USA; 3Visual and Autonomous Exploration Systems Research Laboratory, University of Arizona, Tucson, AZ,
Raffa RB, Fink W, Tripathi AD
doaj   +8 more sources

The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells. [PDF]

J Gen Physiol, 2022
The sympathetic nervous system fight-or-flight response is characterized by a rapid increase in heart rate, which is mediated by an increase in the spontaneous action potential (AP) firing rate of pacemaker cells in the sinoatrial node. Sympathetic neurons stimulate sinoatrial myocytes (SAMs) by activating β adrenergic receptors (βARs) and increasing ...
Peters CH, Rickert C, Morotti S, Grandi E, Aronow KA, Beam KG, Proenza C.   +6 more
europepmc   +7 more sources

Rad regulation of Ca_V1.2 channels controls cardiac fight-or-flight response. [PDF]

Nat Cardiovasc Res, 2022
AbstractFight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. In the present study, we uncover the primary mechanism underlying the heart’s innate contractile reserve. We show that four protein kinase A (PKA)-phosphorylated residues in Rad, a calcium channel inhibitor, are crucial for controlling basal ...
Papa A, Zakharov SI, Katchman AN, Kushner JS, Chen BX, Yang L, Liu G, Jimenez AS, Eisert RJ, Bradshaw GA, Dun W, Ali SR, Rodriques A, Zhou K, Topkara V, Yang M, Morrow JP, Tsai EJ, Karlin A, Wan E, Kalocsay M, Pitt GS, Colecraft HM, Ben-Johny M, Marx SO.   +24 more
europepmc   +5 more sources

Molecular mechanism of calcium channel regulation in the fight-or-flight response. [PDF]

Sci Signal, 2010
Stimulation of cardiac Ca 2+ channel activity by PKA in the fight-or-flight response requires an autoinhibitory complex with the distal C-terminal domain and a kinase anchoring protein.
Fuller MD, Emrick MA, Sadilek M, Scheuer T, Catterall WA.   +4 more
europepmc   +6 more sources

Microbial Colonization Activates an Immune Fight-and-Flight Response via Neuroendocrine Signaling. [PDF]

Dev Cell, 2019
The ability to distinguish harmful and beneficial microbes is critical for the survival of an organism. Here, we show that bloating of the intestinal lumen of Caenorhabditis elegans caused by microbial colonization elicits a microbial aversion behavior.
Singh J, Aballay A.
europepmc   +5 more sources

Phosphorylation sites required for regulation of cardiac calcium channels in the fight-or-flight response. [PDF]

Proc Natl Acad Sci U S A, 2013
Significance This work defines the in vivo role of phosphorylation of Ser1700 and Thr1704 in Ca V 1.2 channels in the fight-or-flight response. Mutation of both residues to Ala in STAA mice reduced basal L-type Ca 2+ currents and ...
Fu Y, Westenbroek RE, Scheuer T, Catterall WA.   +3 more
europepmc   +5 more sources

Na/K-ATPase--an integral player in the adrenergic fight-or-flight response. [PDF]

Trends Cardiovasc Med, 2009
During activation of the sympathetic nervous system, cardiac performance is increased as part of the fight-or-flight stress response. The increase in contractility with sympathetic stimulation is an orchestrated combination of intrinsic inotropic, lusitropic, and chronotropic effects, mediated in part by activation of beta-adrenergic receptors and ...
Bers DM, Despa S.
europepmc   +5 more sources

The fight-or-flight response is associated with PBMC expression profiles related to immune defence and recovery in swine. [PDF]

PLoS ONE, 2015
Defining phenotypes according to molecular features would promote the knowledge of functional traits like behaviour in both human and animal research.
Michael Oster, Mathias Scheel, Eduard Muráni, Siriluck Ponsuksili, Manuela Zebunke, Birger Puppe, Klaus Wimmers   +6 more
doaj   +2 more sources

Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response. [PDF]

Curr Mol Pharmacol, 2015
Intracellular calcium transients generated by activation of voltage-gated calcium (CaV) channels generate local signals, which initiate physiological processes such as secretion, synaptic transmission, and excitation-contraction coupling. Regulation of calcium entry through CaV channels is crucial for control of these physiological processes.
Catterall WA.
europepmc   +4 more sources

How Ca²⁺ influx is attenuated in the heart during a "fight or flight" response. [PDF]

J Gen Physiol, 2019
Bazmi and Escobar highlight a recent investigation of the mechanisms that regulate Ca2+ influx during sympathetic stimulation.
Bazmi M, Escobar AL.
europepmc   +7 more sources