Results 41 to 50 of about 4,343 (260)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Reasoning deficits among illicit drug users are associated with aspects of cannabis use [PDF]

, 2014
Background. Deficits in deductive reasoning have been observed among ecstasy/polydrug users. The present study seeks to investigate dose-related effects of specific drugs and whether these vary with the cognitive demands of the task. Methods. One hundred
AB Scholey, Andy M. Morley, AS Gilinsky, BF Zaldívar, C Montgomery, C Reverberi, C Reverberi, C Shikishima, C Shikishima, C Vignali, Catharine Montgomery, D Rodriguez-Moreno, F Hadjiefthyvoulou, F Indlekofer, Florentia Hadjiefthyvoulou, G Bedi, G Jager, G Jager, G Kanayama, GS Yacoubian Jr, J Raven, JE Fisk, JM Bland, John E. Fisk, KJ Gilhooly, KJ Gilhooly, KM Galotti, LK Jacobsen, M Bucciarelli, MJ Fernández-Serrano, MW Morris, N Pike, N Verschueren, PJ Cunha, PN Johnson-Laird, PN Murphy, S Khemlani, S Nakagawa, SR Narum, V Goel, Y Benjamini   +40 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Local and global gestalt laws: A neurally based spectral approach [PDF]

, 2016
A mathematical model of figure-ground articulation is presented, taking into account both local and global gestalt laws. The model is compatible with the functional architecture of the primary visual cortex (V1).
Citti, Giovanna, Favali, Marta, Sarti, Alessandro   +2 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Frontal lobe regulation of blood glucose levels: support for the limited capacity model in hostile violence-prone men [PDF]

, 2016
Hostile men have reliably displayed an exaggerated sympathetic stress response across multiple experimental settings, with cardiovascular reactivity for blood pressure and heart rate concurrent with lateralized right frontal lobe stress (Trajanoski et al.
David W. Harrison, Patti Kelly Harrison, Ransom W. Campbell, Robert P. Walters   +3 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Nonparametric Conditional Inference for Regression Coefficients with Application to Configural Polysampling [PDF]

, 2007
We consider inference procedures, conditional on an observed ancillary statistic, for regression coefficients under a linear regression setup where the unknown error distribution is specified nonparametrically.
Ho, Yvonne, Lee, Stephen
core   +1 more source