Additional file 11: Figure S11. of HiCPlotter integrates genomic data with interaction matrices
, 2015 An example region for no significant linear genomic signal changes even though genome architecture changes in the highlighted region. a Hi-C contact maps are visualized as heatmaps for GM12878 and K562 cells. Histograms representing DNAseI hypersensitivity (b), RNA-Seq expression (c) and Repli-Seq signals (d) for each type.
Akdemir, Kadir, Chin, Lynda
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Additional file 4: Figure S4. of HiCPlotter integrates genomic data with interaction matrices
, 2015 Example visualization of 4C and ChIP-Seq data as histograms with HiCPlotter. Interaction matrix of mouse embryonic stem cells displayed as heatmaps (a) and rotated half matrix (b), in which the range of the rotated half matrix is 8 megabases from the diagonal.
Akdemir, Kadir, Chin, Lynda
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Are the Cognitive Processes Underlying Practical Intelligence Redundant with Those Underlying Traditional Intelligence [PDF]
, 2000 non
Rauscher, Shari
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Additional file 5: Figure S5. of HiCPlotter integrates genomic data with interaction matrices
, 2015 Example visualization of RAP-Seq data as histograms with HiCPlotter. a Interaction matrix of mouse embryonic stem cells displayed as a heatmap. b Histograms representing RAP-Seq genomic assay signals: five tracks are displayed for Xist localization across the X chromosome at five time points (Xist_0h, Xist_1h, Xist_2h, Xist_3h, and Xist_6h) after Xist ...
Akdemir, Kadir, Chin, Lynda
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Food for thought: Association between dietary tyrosine and cognitive performance in younger and older adults [PDF]
, 2019 The fact that tyrosine increases dopamine availability that, in turn, may enhance cognitive performance has led to numerous studies on healthy young participants taking tyrosine as a food supplement. As a result of this dietary intervention, participants
Brandmaier, A. +7 more
core +3 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Additional file 3: Figure S3. of HiCPlotter integrates genomic data with interaction matrices
, 2015 Example visualization of 5C interaction data with HiCPlotter. Interaction matrices of mouse embryonic stem cells (mESC), mESCs with Xist deletion (mESC_XO) and mouse embryonic fibroblast cells (MEF) displayed as heatmaps (a) and rotated half matrix (b), in which the range of the rotated half matrix is 50 bins from the diagonal. (PDF 219 kb)
Akdemir, Kadir, Chin, Lynda
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Improvements and future challenges for the research infrastructure in the field “Measuring cognitive ability” [PDF]
The assessment of cognitive abilities is critical in large-scale survey studies that aim at elucidating the longitudinal interplay between the individual’s cognitive potential and socio-economic variables.
Elsbeth Stern, Roland H. Grabner
core