Results 71 to 80 of about 14,162 (284)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A marriage of convenience or an amicable divorce: Metaphorical blends in the debates on Brexit
ExELL (Explorations in English Language and Linguistics), 2017 The paper investigates the interaction of conceptual blending and conceptual metaphor in producing figurative creativity in discourse. The phenomenon of figurative creativity is defined by Kövecses (2005) as creativity arising through the cognitive ...
Berberović Sanja, Mujagić Mersina
doaj +1 more source
This chapter will address the following questions: What is figurative language,and how does it differ from ‘literal’ or ‘zero-degree’ communication? When doesa figure of speech become humorous? And how does figurativeness relate to key concepts in linguistic theories of humor, such as script opposition?
Godioli, Alberto +1 more
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
FIGURATIVE LANGUAGE IN THREE EMINEM\u27S SONGS
, 2022 Language can not be taken as it is, in semantics, there is figurative language that is used as an expression and not by its literal meaning. This research analyzed figurative language in three Eminem’s songs entitled Mockingbird, When I\u27m Gone, and ...
Yuwita, Mia Rahmawati, Albion, Lenno
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
"As fayre an handid man" : Malory's figurative language
, 2018 Figurative language in Malory is not very varied, but is strongly connected to chivalry and the community standards that uphold it. This paper deals briefly with set figurative phrases, but focuses on similes and some other figurative phrases, especially
Hildebrand, Kristina,
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
IJOTL-TL (Indonesian Journal of Language Teaching and Linguistics), 2017 The aim of this research is to find out the usage of figurative language appear in The Room of My Life’s poem by Anne Sexton and Still I Rise’s poem by Maya Angelou. The study focused on kinds of figurative language that appeared in the poems.
Ary Iswanto Wibowo, Ali Akbar
doaj +1 more source