Results 1 to 10 of about 321 (221)

Why language really is not a communication system

open access: yesFrontiers in Psychology, 2015
While most evolutionary scenarios for language see it as a communication system with consequences on the language-ready brain, there are major difficulties for such a view. First, language has a core combination of features—semanticity, discrete infinity,
Anne Colette Reboul
doaj   +1 more source

The shape of the language-ready brain

open access: yesFrontiers in Psychology, 2014
Our core hypothesis is that the emergence of our species-specific language-ready brain ought to be understood in light of the developmental changes expressed at the levels of brain morphology and neural connectivity that occurred in our species after the
Cedric Arnaud Boeckx   +2 more
doaj   +1 more source

Thermal response of main protease of SARS and COVID-19 via a coarse-grained approach

open access: yesAIP Advances, 2022
Large-scale Monte Carlo simulations are performed to investigate local and global thermodynamic properties of the main protease in SARS (MP1) and COVID-19 (MP2) coronaviruses using a bond-fluctuating coarse-grained protein model for a range of ...
Panisak Boonamnaj   +2 more
doaj   +1 more source

Like father, like son: assessment of the morphological affinities of A.L. 288-1 (A. afarensis), Sts 7 (A. africanus) and Omo 119-73-2718 (Australopithecus sp.) through a three-dimensional shape analysis of the shoulder joint.

open access: yesPLoS ONE, 2015
The postcranial evidence for the Australopithecus genus indicates that australopiths were able bipeds; however, the morphology of the forelimbs and particularly that of the shoulder girdle suggests that they were partially adapted to an arboreal ...
Julia Arias-Martorell   +3 more
doaj   +1 more source

Mucoadhesive Polymer Hyaluronan as Biodegradable Cationic/Zwitterionic-Drug Delivery Vehicle

open access: yesADMET and DMPK, 2015
Mucoadhesive polymers in pharmaceutical formulations release drugs in mucosal areas. They interact and fix to mucus via molecular interpenetration, etc., which increase drug bioavailability.
Francisco Torrens, Gloria Castellano
doaj   +1 more source

Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry
New thymol–3,4-disubstitutedthiazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 6b, 6d, 6e, and 6f displayed in vitro inhibitory activity against COX-2 (IC50= 0.037, 0.042, 0.046, and 0.039 µM) nearly equal to celecoxib (IC50= 0 ...
Mostafa M. M. El-Miligy   +4 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of 2,6-bis[4-(ethoxycarbonyl)-5-methylpyrazol-1-yl]pyridine

open access: yesActa Crystallographica Section E: Crystallographic Communications
The title compound (systematic name: ethyl 1-{6-[4-(ethoxycarbonyl)-5-methylpyrazol-1-yl]pyridin-2-yl}-5-methylpyrazole-4-carboxylate), C19H21N5O4, consists of a central pyridine ring substituted by two functionalized pyrazole rings and crystallizes in ...
Yevhen Krokhmaliuk   +5 more
doaj   +1 more source

Nouvelles données sur les caractéristiques morphologiques immatures du crâne chez les Homo erectus asiatiques

open access: yesBulletins et Mémoires de la Société d’Anthropologie de Paris, 2007
It is critical to be able to recognize the juvenile specimens within the fossil record in order to determine the adult variability of the different taxa and to approach their ontogenetic and phylogenetic characteristics.
Antoine Balzeau
doaj   +1 more source

Testing the adaptive value of gastropod shell morphology to flow: a multidisciplinary approach based on morphometrics, computational fluid dynamics and a flow tank experiment

open access: yesZoological Letters, 2019
A major question in stream ecology is how invertebrates cope with flow. In aquatic gastropods, typically, larger and more globular shells with larger apertures are found in lotic (flowing water) versus lentic (stagnant water) habitats.
Gerlien Verhaegen   +5 more
doaj   +1 more source

Simple sequence proteins in prokaryotic proteomes

open access: yesBMC Genomics, 2006
Background The structural and functional features associated with Simple Sequence Proteins (SSPs) are non-globularity, disease states, signaling and post-translational modification.
Ramachandran Srinivasan   +2 more
doaj   +1 more source

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