Results 31 to 40 of about 2,061 (261)

Mucoadhesive Polymer Hyaluronan as Biodegradable Cationic/Zwitterionic-Drug Delivery Vehicle

ADMET and DMPK, 2015
Mucoadhesive polymers in pharmaceutical formulations release drugs in mucosal areas. They interact and fix to mucus via molecular interpenetration, etc., which increase drug bioavailability.
Francisco Torrens, Gloria Castellano
doaj   +1 more source

Temperature dependence of normal mode reconstructions of protein dynamics

, 2008
Normal mode analysis is a widely used technique for reconstructing conformational changes of proteins from the knowledge of native structures. In this Letter, we investigate to what extent normal modes capture the salient features of the dynamics over a ...
Cecconi, Fabio, Piazza, Francesco, Rios, Paolo De Los   +2 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Novel diastereoisomers of C21H20O3 obtained from the cathodic reduction of methyl (2E)-3-[2-(2-{2-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)phenyl]prop-2-enoate [PDF]

, 2017
The diastereoisomeric title compounds, 5 and 6, were obtained as a result of intramolecular electrohydrocyclisation of methyl (2E)-3-[2- (2-{2-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)phenyl]prop-2-enoate.
Curilazo, Ricardo, Pardine, Vera L, Tiekink, Edward R. T. *, Viertler, Hans, Zukerman-Schpector, Julio   +4 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Binary globular clusters

New Astronomy, 2000
The dynamics of a close binary system of globular clusters is considered. It is shown that the star transfer process from one of the components to the other should lead to the decrease of dimension of the first cluster with simultaneous increase of the dimension of the second cluster.
openaire   +2 more sources

On the origin of the Boson peak in globular proteins

, 2006
We study the Boson Peak phenomenology experimentally observed in globular proteins by means of elastic network models. These models are suitable for an analytic treatment in the framework of Euclidean Random Matrix theory, whose predictions can be ...
Akasaka K, Ansari A, Atilgan AR, Banavar JR, Buchenau U, Ciliberti S, Ciliberti S, De Los Rios P, Demirel MC, Doster W, Doster W, F. Piazza, Frauenfelder H, Frauenfelder H, Frauenfelder H, Frishman D, Fuentes EJ, Green JL, Grigera TS, Grigera TS, Götze W, Haliloglu T, Hao MH, Heremans K, Hinsen K, Hung AY, Iben IET, Karpov VG, Leyser H, Martín-Mayor V, Micheletti C, Mézard M, Onuchic JN, Orecchini A, P. De Los Rios, Pawson T, Piazza F, S. Ciliberti, Schirmacher W, Sheng M, Tama F, Taraskin SN, Tirion MM, Voigtmann T, Wyart M, Xie A, Yamato T   +46 more
core   +1 more source

JABAWS 2.2 Distributed Web Services for Bioinformatics:Protein Disorder, Conservation and RNA Secondary Structure [PDF]

, 2018
Summary JABAWS 2.2 is a computational framework that simplifies the deployment of web services for Bioinformatics. In addition to the five multiple sequence alignment (MSA) algorithms in JABAWS 1.0, JABAWS 2.2 includes three additional ...
Barton, Daniel L., Barton, Geoffrey J., Madeira, Fábio, Procter, James B., Sherstnev, Alexander, Troshin, Peter V.   +5 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof

Journal of Enzyme Inhibition and Medicinal Chemistry
New thymol–3,4-disubstitutedthiazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 6b, 6d, 6e, and 6f displayed in vitro inhibitory activity against COX-2 (IC50= 0.037, 0.042, 0.046, and 0.039 µM) nearly equal to celecoxib (IC50= 0 ...
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Rasha A. Nassra, Saad R. El-Zemity, Aly A. Hazzaa   +4 more
doaj   +1 more source