Results 41 to 50 of about 1,150 (267)

Bioinformatic and Experimental Evaluation of Compounds Targeting Acinetobacter baumannii

Trends in Pharmacy
Background: This study combined cheminformatics and in vitro approaches to identify novel antimicrobial compounds against Acinetobacter baumannii, a major multidrug- resistant ESKAPE pathogen.
Eslem Mert, Ebru Yücebağ Duranay
doaj   +5 more sources

Diffusion and Mixing in Globular Clusters [PDF]

The Astrophysical Journal, 2018
Abstract Collisional relaxation describes the stochastic process with which a self-gravitating system near equilibrium evolves in phase-space due to the fluctuating gravitational field of the system. The characteristic timescale of this process is called the relaxation time. In this paper, we highlight the difference between two measures
Yohai Meiron, Bence Kocsis
openaire   +4 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Association of Partially-folded Intermediates of Staphylococcal Nuclease Induces Structure and Stability [PDF]

, 1999
Staphylococcal nuclease forms three different partially-folded intermediates at low pH in the presence of low to moderate concentration of anions, differing in the amount of secondary structure, globularity, stability, and compactness.
Karnoup, Anton S., Fink, Anthony L., Uversky, Vladimir N., Khurana, Ritu, Segel, Daniel J., Doniach, Sebastian   +5 more
core   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Association-induced Folding of Globular Proteins [PDF]

, 1998
It has generally been assumed that the aggregation of partially folded intermediates during protein refolding results in the termination of further protein folding.
Fink, Anthony L., Uversky, Vladimir N., Segel, Daniel J., Doniach, Sebastian   +3 more
core   +1 more source

The emergence of globular clusters and globular-cluster-like dwarfs

Nature
Abstract Globular clusters (GCs) are among the oldest and densest stellar systems in the Universe, yet how they form remains a mystery1. Here we present a suite of cosmological simulations in which both dark-matter-free GCs and dark-matter-rich dwarf galaxies naturally emerge in the Standard Cosmology.
Ethan D. Taylor, Justin I. Read, Matthew D. A. Orkney, Stacy Y. Kim, Andrew Pontzen, Oscar Agertz, Martin P. Rey, Eric P. Andersson, Michelle L. M. Collins, Robert M. Yates   +9 more
openaire   +5 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof

Journal of Enzyme Inhibition and Medicinal Chemistry
New thymol–3,4-disubstitutedthiazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 6b, 6d, 6e, and 6f displayed in vitro inhibitory activity against COX-2 (IC50= 0.037, 0.042, 0.046, and 0.039 µM) nearly equal to celecoxib (IC50= 0 ...
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Rasha A. Nassra, Saad R. El-Zemity, Aly A. Hazzaa   +4 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source