Results 121 to 130 of about 21,508 (266)

CARD14 gain-of-function mutation alone is sufficient to drive IL-23/IL-17-mediated psoriasiform skin inflammation in vivo [PDF]

, 2018
Rare autosomal dominant mutations in the gene encoding the keratinocyte signaling molecule, Caspase Recruitment Domain-Containing Protein 14 (CARD14), have been associated with an increased susceptibility to psoriasis but the physiological impact of ...
Cheng, Phil, Contassot, Emmanuel, French, Lars E, Kiefer, Betina, Meier, Barbara, Mellett, Mark, Mohanan, Deepa, Nobbe, Stephan, Ospelt, Caroline, Satoh, Takashi K, Schairer, Rebekka, Thome, Margot   +11 more
core   +1 more source

P38/ERK MAPK signaling pathways are involved in the regulation of filaggrin and involucrin by IL-17

Molecular Medicine Reports, 2017
Atopic dermatitis (AD) is characterized by a defective skin barrier, which increases the penetration of allergens and pathogens through the skin. The role of interleukin (IL)-17, a pro-inflammatory cytokine, in the pathogenesis of AD remains to be ...
Q. Tan, Huan Yang, E. Liu, Hua Wang
semanticscholar   +1 more source

Contact Sensitization in Adults With Atopic Dermatitis: A 21‐Year Single‐Center Tertiary Experience

Contact Dermatitis, EarlyView.
A graphical abstract has been included as supplemental material. ABSTRACT Background Atopic dermatitis is a common chronic inflammatory skin condition. Data on contact sensitization in adults with atopic dermatitis remain limited. Objectives To investigate the prevalence of contact sensitization in adults with and without AD: Patients/Methods A ...
Francesca Caroppo, Anna Zambello, Giulia Biolo, Fortunato Cassalia, Laura Ventura, Anna Belloni Fortina   +5 more
wiley   +1 more source

10-Hydroxy-2-Decenoic Acid in Royal Jelly Extract Induced Both Filaggrin and Amino Acid in a Cultured Human Three-Dimensional Epidermis Model

Cosmetics, 2017
Royal jelly (RJ) is a natural product which the honeybee secretes as a special diet for a queen bee. It is one of the natural products in which various functionalities, such as antibacterial effects, immunomodulating properties, and estrogen-like action,
Lihao Gu, Haifeng Zeng, Kazuhisa Maeda
doaj   +1 more source

A review of skin microbiome and new challenges to cosmetic microbiome‐friendly formulations

International Journal of Cosmetic Science, EarlyView.
Microbiome‐friendly concepts offer new perspectives for a healthy relationship between cosmetic use and the skin microbiome, especially the interaction of non‐biotic cosmetic ingredients with the skin, requiring further studies to clarify the dynamics between the skin microbiome and different classes of cosmetic ingredients.
Yasmin Rosa Santos, Newton Andréo‐Filho, Patricia Santos Lopes, Vânia Rodrigues Leite‐Silva   +3 more
wiley   +1 more source

Filaggrin and tight junction proteins are crucial for IL-13-mediated esophageal barrier dysfunction.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2018
Eosinophilic esophagitis (EoE) is an allergy-mediated disease that is accompanied by IL-13 overexpression and an impaired esophageal barrier. Filaggrin (FLG) and tight junction (TJ) proteins are considered to contribute to epithelial barrier function ...
Liping Wu, T. Oshima, Min Li, T. Tomita, H. Fukui, J. Watari, H. Miwa   +6 more
semanticscholar   +1 more source

The Pathogenesis of Atopic Dermatitis‐Trends for the Future

The Journal of Dermatology, EarlyView.
Norito Katoh
wiley   +1 more source

Inflammatory niches as spatial drivers of disease mechanisms and targets for personalized treatment

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This study provides a comprehensive review of how spatial transcriptomics reveals disease‐specific inflammatory niches across multiple skin disorders, highlighting key immune–stromal, neuro–immune and metabolic interactions that were previously unappreciated in non‐spatial analyses. Abstract Disease states are increasingly recognized as being shaped by
Rundong Jiang, Zhiqin Fang, Lam C. Tsoi, Johann E. Gudjonsson   +3 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Epistasis between FLG and IL4R genes on the risk of allergic sensitization: results from two population-based birth cohort studies [PDF]

, 2018
Immune-specifc genes as well as genes responsible for the formation and integrity of the epidermal barrier have been implicated in the pathogeneses of allergic sensitization.
A Benedetto De, A Custovic, A Kubo, AD Irvine, AE Kelly-Welch, AH Ziyab, B Omolo, CN Palmer, D Vercelli, DE Comings, DP Potaczek, F Castro-Giner, G Roberts, HF Bunn, IH Chan, K Adjers, K Bonnelykke, LS Penrose, M Granada, M Kabesch, MJ Loza, N Soto-Ramirez, O Zuk, P Cummings, P Kraft, PM Salo, RA Oord van den, S Olson, S Weidinger, SL Zeger, TM Baye, W Pan, WH Wei, WW Busse, X Liu, Y Benjamini, YI Wan   +36 more
core   +2 more sources