Results 91 to 100 of about 285,820 (289)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Filaments [PDF]

Symposium - International Astronomical Union, 1983
I would like to make a brief comment on some work that John Moody, Edwin Turner and I have done on filamentary structure in the Shane-Wirtanen galaxy counts. The picture of the Shane-Wirtanen galaxy counts to the 19th magnitude appears quite filamentary to the eye.
openaire   +1 more source

Mechanical Properties of Thermoplastic Polymers in Fused Filament Fabrication (FFF)

, 2022
Fused filament fabrication (FFF) is a method used to fabricate initial prototypes out of polymeric materials with printed parts often being used as load carrying elements.
Wolfe, T., Bhardwaj, N., Henein, H.
core   +1 more source

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak, Marije M. C. Voermans, Hans Heijst, Charlotte E. Teunissen, Marc Engelen   +4 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Modelling flow-enhanced crystallisation during fused filament fabrication of semi-crystalline polymer melts [PDF]

, 2018
Achieving better control in fused filament fabrication (FFF) relies on a molecular understanding of how thermoplastic printing materials behave during the printing process.
McIlroy, C., Graham, R.S.
core   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Potential utilization of filaments and ovules as explant sources in in vitro propagation of Lilium sp.

Notulae Botanicae Horti Agrobotanici Cluj-Napoca
Lilies are important cut and pot flowers locally and globally; however, qualified planting materials from in vitro culture are still limited. The culture generally uses scales and leaves, while filaments and ovules are rarely utilized.
Budi WINARTO, Suskandari KARTIKANINGRUM, Fitri RACHMAWATI, Dewi PRAMANIK, Herni SHINTIAVIRA, Mega WEGADARA   +5 more
doaj   +1 more source

New Ion Source Filament for Prolonged Ion Source Operation on A Medical Cyclotron

Instruments, 2019
Cyclotrons are an important tool for accelerator sciences including the production of medical isotopes for imaging and therapy. For their successful and cost-efficient operation, the planned and unplanned down time of the cyclotron needs to be kept at a ...
Dave Prevost, Keerthi Jayamanna, Linda Graham, Sam Varah, Cornelia Hoehr   +4 more
doaj   +1 more source