Results 71 to 80 of about 285,820 (289)

Assay for high-throughput screening of inhibitors of the ASC-PYD inflammasome core filament [PDF]

, 2018
The protein ASC is a central component of most inflammasome complexes, forming functional oligomeric filaments that activate large amounts of pro-caspase-1 for further IL-1β processing and the induction of Gasdermin D-dependent cell death.
Jonathan Vesin, Gerardo Turcatti, Hiller, Sebastian, Broz, Petr, Johanna Ude, Chambon, Marc, Lorenzo Sborgi, Ude, Johanna, Vesin, Johnathan, Sebastian Hiller, Turcatti, Gerardo, Dick, Mathias S., Mathias S. Dick, Sborgi, Lorenzo, Marc Chambon, Petr Broz   +15 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The Effect of Filament Materials (Tungsten, Lanthanum Hexaboride) in 250 keV/1 mA Electron Beam Machines on Empirical Capacity of RVNRL

International Journal of Technology
Some types of filaments sold commercially are made of tungsten and a lanthanum hexaboride (LaB6) with a lifetime of approximately 30-100 hours and > 1000 hours, respectively.
Herry Poernomo, Suhadah Rabi'atul Adabiah, Darsono Darsono, Suprapto Suprapto, Djoko Slamet Pudjorahardjo, Samin Samin, Kris Tri Basuki   +6 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Mechanically sustainable and primary recycled thermo-responsive ABS–PLA polymer composites for 4D printing applications: Fabrication and studies

Reviews on Advanced Materials Science
3D printing is one of the plastic recycling processes that deliver a mechanically sustainable product and may be used for 4D printing applications, such as self-assembly, sensors, actuators, and other engineering applications.
Thakur Vishal, Singh Rupinder, Kumar Ranvijay, Sharma Shubham, Singh Sunpreet, Li Changhe, Zhang Yanbin, Eldin Sayed M., Alqarni Sondos Abdullah   +8 more
doaj   +1 more source

Upcycling Waste Polyethylene Terephthalate Bottles into Eco-Friendly Filaments for Material Extrusion 3D Printing

Engineered Science
In this study, waste polyethylene terephthalate (PET) drinking water bottles were upcycled into 3D-printing filaments to reduce the carbon footprint of a material extrusion process.
Siriwan Pongsathit, Peerapong Chanthot, Syang-Peng Rwei, Cattaleeya Pattamaprom   +3 more
doaj   +1 more source

Effects of Fodder and Sericin Degumming Agents on Asunder Filament of Golden Silkworm Cocoon of Cricula trifenestrata Helf

Jurnal Ilmu Kehutanan, 2013
The research aim was to obtain the effect of fodder and sericin degumming agents on asunder filament of golden silkworm cocoon of Cricula trifenestrata Helf.
Terry M Frans
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

ON FILAMENTOUS ENTOZOA. [PDF]

The Lancet
n ...
openaire   +2 more sources

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source