Results 61 to 70 of about 259,788 (307)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2023 Purpose: This study/paper aims to develop fundamental understanding of mechanical properties for multiple fibre-reinforced materials by using a single-filament-wide tensile-testing approach. Design/methodology/approach: In this study, recently validated
Jiongyi Yan (7442516) +2 more
core
Expression of chicken lamin B2 in Escherichia coli : characterization of its structure, assembly, and molecular interactions [PDF]
, 1991 Chicken lamin B2, a nuclear member of the intermediate-type filament (IF) protein family, was expressed as a full-length protein in Escherichia coli.
Aebi, U. +11 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
On the hyperspaces of meager and regular continua
Applied General TopologyGiven a metric continuum X, we consider the collection of all regular subcontinua of X and the collection of all meager subcontinua of X, these hyperspaces are denoted by D(X) and M(X), respectively.
Javier Camargo +2 more
doaj +1 more source
A closed form solution for the proximity effect in a thin tubular conductor influenced by a parallel filament [PDF]
Serbian Journal of Electrical Engineering, 2010 The present paper deals with the proximity effect in a system consisting of a thin tubular conductor and a filament. The integral equation for the current density in the tubular conductor is solved by assuming a solution in the form of an infinite ...
Filipović Dragan, Dlabač Tatijana
doaj +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Guidance of Actin Filament Elongation on Filament-Binding Tracks
, 2016 Biomolecular motors, which convert chemical energy into mechanical work in intracellular processes, have high potential in bionanotechnology in vitro as molecular shuttles or nanoscale actuators.
Suzanne A. Ciftan-Hens (2469697) +5 more
core +5 more sources
The Effect of 3D Printer Head Extruder Design on Dynamics and Print Quality
Applied SciencesIn 3D-printing variations using FFF technology, the extruder governs printer efficiency. One of the important parameters is its weight, which affects the dynamics of the print head.
Marek Wozniak +4 more
doaj +1 more source