Results 1 to 10 of about 566 (120)

Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis

Biomedicines, 2021
Onchocerciasis is the leading cause of blindness and severe skin lesions which remain a major public health problem, especially in tropical areas. The widespread use of antibiotics and the long duration required for effective treatment continues to add ...
Michael Wilson, Emmanuel Broni, Whelton Miller   +2 more
exaly   +3 more sources

Filaricidal activity of Daniellia oliveri and Psorospermum febrifugum extracts [PDF]

Parasites & Vectors, 2021
Abstract Background Drugs currently used for controlling onchocerciasis and lymphatic filariasis (LF) are mainly microfilaricidal, with minimal or no effect on the adult worms. For efficient management of these diseases, it is necessary to search for new drugs with macrofilaricidal activities that can be used singly or ...
Melanie Abongwa, Moses Samje, Godfred A. Ayimele, Smith B. Babiaka, Christina Bulman, Judy Sakanari, Nick J. Koszewski, Saurabh Verma, Jesse Goff, Fidelis Cho-Ngwa, Richard J. Martin, Alan P. Robertson   +11 more
openaire   +3 more sources

Human dirofilariosis in the 21st century: A scoping review of clinical cases reported in the literature

Transboundary and Emerging Diseases, Volume 69, Issue 5, Page 2424-2439, September 2022., 2022
Abstract Human dirofilariosis is a clinical entity caused by infection with nematode species of the genus Dirofilaria. The traditional picture depicts the disease as a sporadic event associated with the presence of a single immature worm causing a nodular lesion.
Fernando Simón, Alicia Diosdado, Mar Siles‐Lucas, Vladimir Kartashev, Javier González‐Miguel   +4 more
wiley   +1 more source

Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon

Journal of Parasitology Research, Volume 2022, Issue 1, 2022., 2022
Onchocerciasis is a parasitic infection affecting a relatively small population globally but has very devastating pathological outcomes. Ivermectin and recently moxidectin are the only drugs approved for clinical management of the disease, both of which have several limitations.
Thierry Roland Kang, Jerome Nyhalah Dinga, Ayuk Elizabeth Orock, Elvis Monya, Moses Njutain Ngemenya, Lizandra Guidi Magalhães   +5 more
wiley   +1 more source

Recent Advances on the Use of Biochemical Extracts as Filaricidal Agents [PDF]

Evidence-Based Complementary and Alternative Medicine, 2013
Lymphatic filariasis is a parasitic infection that causes a devastating public health and socioeconomic burden with an estimated infection of over 120 million individuals worldwide. The infection is caused by three closely related nematode parasites, namely,Wuchereria bancrofti,Brugia malayi, andB.
Al-Abd, Nazeh M., Nor, Zurainee Mohamed, Al-Adhroey, Abdulelah H., Suhaimi, Anwar, Sivanandam, S.   +4 more
openaire   +3 more sources

Selective activity of extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi

BMC Complementary and Alternative Medicine, 2010
Background The current treatment of onchocerciasis relies on the use of ivermectin which is only microfilaricidal and for which resistant parasite strains of veterinary importance are increasingly being detected.
Nyongbela Kennedy D, Ngemenya Moses N, Abongwa Melanie, Cho-Ngwa Fidelis   +3 more
doaj   +1 more source

Dirofilaria immitis Microfilariae and Third-Stage Larvae Induce Canine NETosis Resulting in Different Types of Neutrophil Extracellular Traps

Frontiers in Immunology, 2018
Heartworm disease is a zoonotic vector-borne disease caused by Dirofilaria immitis mainly affecting canids. Infectious third-stage larvae (L3) are transmitted to the definitive hosts via culicid mosquitoes; adult nematodes reside in the pulmonary ...
Tamara Muñoz-Caro, Iván Conejeros, Ershun Zhou, Anton Pikhovych, Ulrich Gärtner, Carlos Hermosilla, Daniel Kulke, Anja Taubert   +7 more
doaj   +1 more source

The Diversity of Human Dirofilariasis in Western Sri Lanka

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
Background. Human dirofilariasis is an emerging zoonosis in many countries. Dirofilariasis caused by Dirofilaria repens may present with diverse clinical manifestations in humans due to aberrant localization of worm lesions causing diagnostic dilemmas.
T. G. A. N. Chandrasena, R. Premaratna, C. H. Mallawaarachchi, N. K. Gunawardena, P. A D. H. N. Gunathilaka, W. Y. Abeyewickrama, N. R. de Silva, Francesca Mancianti   +7 more
wiley   +1 more source

Streblus asper Lour. (Shakhotaka): A Review of its Chemical, Pharmacological and Ethnomedicinal Properties

Evidence-Based Complementary and Alternative Medicine, Volume 3, Issue 2, Page 217-222, 2006., 2006
Streblus asper Lour is a small tree found in tropical countries, such as India, Sri Lanka, Malaysia, the Philippines and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as filariasis, leprosy, toothache, diarrhea, dysentery and cancer.
Subha Rastogi, Dinesh K. Kulshreshtha, Ajay Kumar Singh Rawat   +2 more
wiley   +1 more source

A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis

Parasites & Vectors, 2014
Background New drugs effective against adult filariae (macrofilaricides) would accelerate the elimination of lymphatic filariasis and onchocerciasis. Anti-Onchocerca drug development is hampered by the lack of a facile model. We postulated that SCID mice
Alice Halliday, Ana F Guimaraes, Hayley E Tyrer, Haelly Mejane Metuge, Chounna Ndongmo Winston Patrick, Kengne-Ouafo Jonas Arnaud, Tayong Dizzle Bita Kwenti, George Forsbrook, Andrew Steven, Darren Cook, Peter Enyong, Samuel Wanji, Mark J Taylor, Joseph D Turner   +13 more
doaj   +1 more source