Results 111 to 120 of about 1,700,069 (268)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Channel Coding for Power Line Communication Based on Oversampled Filter Banks
, 2005 Oversampled filter banks (OSFB) can be applied as channel coding and have shown benefits in correlated and impulsive noise. Therefore, in this paper, we consider such channel coders for a power line communications scenario, where such conditions create a
Redif, S +17 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Assesing HP Filter Performance for Argentina and U.S. Macro Aggregates [PDF]
Hodrick-Prescott filter has been the favourite empirical technique among researchers studying "cycles". Software facilities and the optimality criterion, from which the filter can be derived, can explain its wide use.
María Lorena Garegnani +1 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Generalised Linear and Nonlinear Spline filter
In this paper, a generalised spline filter, that has a unified description for both the linear spline filter and the nonlinear robust spline filter, is proposed.
Zeng, Wenhan +2 more
core
An 'active' passive-filter topology for low power DC/AC inverters
, 2011 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis presents a new output passive filter for voltage source inverter applications which is based on a shunt connected single tuned filter topology ...
Arman, Mahmoud Fayez
core
International Journal of Mathematics and Mathematical Sciences, 1985 In this note, we show that if a topology F¯ over a ring A satisfies a certain finiteness condition, then the Gabriel topology G¯ generated by F¯ can be explicitly constructed and it also satisfies the same finiteness condition.
Syed M. Fakhruddin
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source